Metabolic Salvage and Acyl-chain Remodeling Support Glycosphingolipid Synthesis within the PDAC Tumor Microenvironment.

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Title: Metabolic Salvage and Acyl-chain Remodeling Support Glycosphingolipid Synthesis within the PDAC Tumor Microenvironment.
Authors: Trimble AS; Department of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA.; Department of Molecular and Cell Biology, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Kubota CS; Department of Molecular and Cell Biology, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.; Department of Regulatory Biology, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Zhao E; Department of Molecular and Cell Biology, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.; Department of Biological Sciences, University of California San Diego, La Jolla, CA, 92093, USA., Ruchhoeft ML; Department of Molecular and Cell Biology, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Weitz JR; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, UC San Diego, La Jolla, CA, 92131, USA., Jung W; Department of Oncology Science, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA., Peck KL; Department of Regulatory Biology, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Ogawa S; Department of Regulatory Biology, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Ashley EL; Department of Molecular and Cell Biology, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.; Department of Biological Sciences, University of California San Diego, La Jolla, CA, 92093, USA., Tiriac H; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, UC San Diego, La Jolla, CA, 92131, USA., Oh TG; Department of Oncology Science, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.; OU Health Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, OK, 73104, USA., Lowy AM; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, UC San Diego, La Jolla, CA, 92131, USA., Engle DD; Department of Regulatory Biology, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.; Department of Biological Sciences, University of California San Diego, La Jolla, CA, 92093, USA., Metallo CM; Department of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA.; Department of Molecular and Cell Biology, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 05. Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.64898/2026.04.14.718544