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D-pinitol extends the lifespan of Caenorhabditis elegans through integrated antioxidant defense, proteostasis, and autophagy signaling.

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Title: D-pinitol extends the lifespan of Caenorhabditis elegans through integrated antioxidant defense, proteostasis, and autophagy signaling.
Authors: Shi L; Jiangxi Province Key Laboratory of Aging and Disease, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, Nanchang, China., Liu YL; Jiangxi Province Key Laboratory of Aging and Disease, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, Nanchang, China., Dai MN; Jiangxi Province Key Laboratory of Aging and Disease, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, Nanchang, China., Ma YX; Jiangxi Province Key Laboratory of Aging and Disease, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, Nanchang, China., Wu JN; Jiangxi Province Key Laboratory of Aging and Disease, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, Nanchang, China., Guo L; Jiangxi Province Key Laboratory of Aging and Disease, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, Nanchang, China., Luo L; Jiangxi Province Key Laboratory of Aging and Disease, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, Nanchang, China., Fu HH; Jiangxi Province Key Laboratory of Aging and Disease, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, Nanchang, China., Huang CY; Jiangxi Province Key Laboratory of Aging and Disease, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, Nanchang, China., Zhang JY; Jiangxi Province Key Laboratory of Aging and Disease, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, Nanchang, China., Kou YN; Jiangxi Province Key Laboratory of Aging and Disease, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, Nanchang, China., Luo HR; Jiangxi Province Key Laboratory of Aging and Disease, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, Nanchang, China., Wu GS; Jiangxi Province Key Laboratory of Aging and Disease, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, Nanchang, China. guishengwu@ncu.edu.cn.
Source: Npj aging [NPJ Aging] 2026 Apr 27; Vol. 12 (1). Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918402285106676 Publication Model: Electronic Cited Medium: Internet ISSN: 2731-6068 (Electronic) Linking ISSN: 27316068 NLM ISO Abbreviation: NPJ Aging Subsets: In Process
Database: MEDLINE Ultimate
Description
ISSN:2731-6068
DOI:10.1038/s41514-026-00381-x