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An Immune Dysfunction Signature Score Predicts Survival in MDS Patients: Insights From a Longitudinal, Multicenter Study.

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Title: An Immune Dysfunction Signature Score Predicts Survival in MDS Patients: Insights From a Longitudinal, Multicenter Study.
Authors: Wang YH; Division of Haematology, National Taiwan University Hospital, Taipei, Taiwan.; Epigenetics of Haematopoiesis Laboratory, Division of Cancer Sciences, The University of Manchester, Manchester, UK.; Department of Hematological Oncology, National Taiwan University Cancer Center, Taipei, Taiwan., Gurnari C; Department of Translational Haematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy., Visconte V; Department of Translational Haematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA., Durmaz A; Department of Translational Haematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA., Guarnera L; Department of Translational Haematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA., Lee WH; Division of Haematology, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Hospital, Hsinchu City, Taiwan., Yao CY; Division of Haematology, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan., Jerez A; Haematology Department, Hospital Morales Meseguer, Murcia, Spain., Gurashi K; Epigenetics of Haematopoiesis Laboratory, Division of Cancer Sciences, The University of Manchester, Manchester, UK., Batta K; Epigenetics of Haematopoiesis Laboratory, Division of Cancer Sciences, The University of Manchester, Manchester, UK., Hou HA; Division of Haematology, National Taiwan University Hospital, Taipei, Taiwan., Chou WC; Division of Haematology, National Taiwan University Hospital, Taipei, Taiwan.; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan., Patnaik MS; Mayo Clinic College of Medicine, Rochester, Minnesota, USA., Maciejewski J; Department of Translational Haematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA., Wiseman DH; Epigenetics of Haematopoiesis Laboratory, Division of Cancer Sciences, The University of Manchester, Manchester, UK., Lin CC; Division of Haematology, National Taiwan University Hospital, Taipei, Taiwan.; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Tien HF; Division of Haematology, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Source: Cancer science [Cancer Sci] 2026 Apr 28. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Publishing on behalf of the Japanese Cancer Association Country of Publication: England NLM ID: 101168776 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7006 (Electronic) Linking ISSN: 13479032 NLM ISO Abbreviation: Cancer Sci Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Wang+YH%22">Wang YH</searchLink>; Division of Haematology, National Taiwan University Hospital, Taipei, Taiwan.; Epigenetics of Haematopoiesis Laboratory, Division of Cancer Sciences, The University of Manchester, Manchester, UK.; Department of Hematological Oncology, National Taiwan University Cancer Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Gurnari+C%22">Gurnari C</searchLink>; Department of Translational Haematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Visconte+V%22">Visconte V</searchLink>; Department of Translational Haematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Durmaz+A%22">Durmaz A</searchLink>; Department of Translational Haematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Guarnera+L%22">Guarnera L</searchLink>; Department of Translational Haematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Lee+WH%22">Lee WH</searchLink>; Division of Haematology, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Hospital, Hsinchu City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yao+CY%22">Yao CY</searchLink>; Division of Haematology, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Jerez+A%22">Jerez A</searchLink>; Haematology Department, Hospital Morales Meseguer, Murcia, Spain.<br /><searchLink fieldCode="AU" term="%22Gurashi+K%22">Gurashi K</searchLink>; Epigenetics of Haematopoiesis Laboratory, Division of Cancer Sciences, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Batta+K%22">Batta K</searchLink>; Epigenetics of Haematopoiesis Laboratory, Division of Cancer Sciences, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Hou+HA%22">Hou HA</searchLink>; Division of Haematology, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chou+WC%22">Chou WC</searchLink>; Division of Haematology, National Taiwan University Hospital, Taipei, Taiwan.; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Patnaik+MS%22">Patnaik MS</searchLink>; Mayo Clinic College of Medicine, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Maciejewski+J%22">Maciejewski J</searchLink>; Department of Translational Haematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Wiseman+DH%22">Wiseman DH</searchLink>; Epigenetics of Haematopoiesis Laboratory, Division of Cancer Sciences, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Lin+CC%22">Lin CC</searchLink>; Division of Haematology, National Taiwan University Hospital, Taipei, Taiwan.; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tien+HF%22">Tien HF</searchLink>; Division of Haematology, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
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