Preclinical demonstration of the efficacy and mechanisms of antitumor activity of dihydroartemisinin in cholangiocarcinoma xenograft: Induction of autophagy and reprogramming of metabolism.

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Title: Preclinical demonstration of the efficacy and mechanisms of antitumor activity of dihydroartemisinin in cholangiocarcinoma xenograft: Induction of autophagy and reprogramming of metabolism.
Authors: Thongchot S; Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand; Department of Systems Biosciences and Computational Medicine, Faculty of Medicine, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro, Via Solaroli 17, Novara 28100, Italy; Cholangiocarcinoma Research Institute, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand., Kittirat Y; Department of Systems Biosciences and Computational Medicine, Faculty of Medicine, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Regional Medical Science Center 2 Phitsanulok, Department of Medical Sciences, Ministry of Public Health, Phitsanulok 65000, Thailand., Promraksa B; Department of Systems Biosciences and Computational Medicine, Faculty of Medicine, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Regional Medical Science Center 2 Phitsanulok, Department of Medical Sciences, Ministry of Public Health, Phitsanulok 65000, Thailand., Ferraresi A; Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro, Via Solaroli 17, Novara 28100, Italy., Vidoni C; Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro, Via Solaroli 17, Novara 28100, Italy., Loilome W; Department of Systems Biosciences and Computational Medicine, Faculty of Medicine, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand., Namwat N; Department of Systems Biosciences and Computational Medicine, Faculty of Medicine, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand. Electronic address: nisana@kku.ac.th., Isidoro C; Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro, Via Solaroli 17, Novara 28100, Italy. Electronic address: ciro.isidoro@med.uniupo.it.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2026 Jun; Vol. 199, pp. 119438. Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1950-6007
DOI:10.1016/j.biopha.2026.119438