Preclinical demonstration of the efficacy and mechanisms of antitumor activity of dihydroartemisinin in cholangiocarcinoma xenograft: Induction of autophagy and reprogramming of metabolism.
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| Title: | Preclinical demonstration of the efficacy and mechanisms of antitumor activity of dihydroartemisinin in cholangiocarcinoma xenograft: Induction of autophagy and reprogramming of metabolism. |
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| Authors: | Thongchot S; Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand; Department of Systems Biosciences and Computational Medicine, Faculty of Medicine, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro, Via Solaroli 17, Novara 28100, Italy; Cholangiocarcinoma Research Institute, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand., Kittirat Y; Department of Systems Biosciences and Computational Medicine, Faculty of Medicine, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Regional Medical Science Center 2 Phitsanulok, Department of Medical Sciences, Ministry of Public Health, Phitsanulok 65000, Thailand., Promraksa B; Department of Systems Biosciences and Computational Medicine, Faculty of Medicine, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Regional Medical Science Center 2 Phitsanulok, Department of Medical Sciences, Ministry of Public Health, Phitsanulok 65000, Thailand., Ferraresi A; Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro, Via Solaroli 17, Novara 28100, Italy., Vidoni C; Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro, Via Solaroli 17, Novara 28100, Italy., Loilome W; Department of Systems Biosciences and Computational Medicine, Faculty of Medicine, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand., Namwat N; Department of Systems Biosciences and Computational Medicine, Faculty of Medicine, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand. Electronic address: nisana@kku.ac.th., Isidoro C; Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro, Via Solaroli 17, Novara 28100, Italy. Electronic address: ciro.isidoro@med.uniupo.it. |
| Source: | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2026 Jun; Vol. 199, pp. 119438. Date of Electronic Publication: 2026 Apr 27. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42048718 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Preclinical demonstration of the efficacy and mechanisms of antitumor activity of dihydroartemisinin in cholangiocarcinoma xenograft: Induction of autophagy and reprogramming of metabolism. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Thongchot+S%22">Thongchot S</searchLink>; Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand; Department of Systems Biosciences and Computational Medicine, Faculty of Medicine, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro, Via Solaroli 17, Novara 28100, Italy; Cholangiocarcinoma Research Institute, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand.<br /><searchLink fieldCode="AU" term="%22Kittirat+Y%22">Kittirat Y</searchLink>; Department of Systems Biosciences and Computational Medicine, Faculty of Medicine, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Regional Medical Science Center 2 Phitsanulok, Department of Medical Sciences, Ministry of Public Health, Phitsanulok 65000, Thailand.<br /><searchLink fieldCode="AU" term="%22Promraksa+B%22">Promraksa B</searchLink>; Department of Systems Biosciences and Computational Medicine, Faculty of Medicine, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Regional Medical Science Center 2 Phitsanulok, Department of Medical Sciences, Ministry of Public Health, Phitsanulok 65000, Thailand.<br /><searchLink fieldCode="AU" term="%22Ferraresi+A%22">Ferraresi A</searchLink>; Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro, Via Solaroli 17, Novara 28100, Italy.<br /><searchLink fieldCode="AU" term="%22Vidoni+C%22">Vidoni C</searchLink>; Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro, Via Solaroli 17, Novara 28100, Italy.<br /><searchLink fieldCode="AU" term="%22Loilome+W%22">Loilome W</searchLink>; Department of Systems Biosciences and Computational Medicine, Faculty of Medicine, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand.<br /><searchLink fieldCode="AU" term="%22Namwat+N%22">Namwat N</searchLink>; Department of Systems Biosciences and Computational Medicine, Faculty of Medicine, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, 123 Mitraparp Highway, Khon Kaen 40002, Thailand. Electronic address: nisana@kku.ac.th.<br /><searchLink fieldCode="AU" term="%22Isidoro+C%22">Isidoro C</searchLink>; Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro, Via Solaroli 17, Novara 28100, Italy. Electronic address: ciro.isidoro@med.uniupo.it. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228213295%22">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</searchLink> [Biomed Pharmacother] 2026 Jun; Vol. 199, pp. 119438. <i>Date of Electronic Publication: </i>2026 Apr 27. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>8213295 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1950-6007 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207533322%22">07533322 </searchLink><i>NLM ISO Abbreviation: </i>Biomed Pharmacother <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42048718 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.biopha.2026.119438 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 119438 Titles: – TitleFull: Preclinical demonstration of the efficacy and mechanisms of antitumor activity of dihydroartemisinin in cholangiocarcinoma xenograft: Induction of autophagy and reprogramming of metabolism. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Thongchot S – PersonEntity: Name: NameFull: Kittirat Y – PersonEntity: Name: NameFull: Promraksa B – PersonEntity: Name: NameFull: Ferraresi A – PersonEntity: Name: NameFull: Vidoni C – PersonEntity: Name: NameFull: Loilome W – PersonEntity: Name: NameFull: Namwat N – PersonEntity: Name: NameFull: Isidoro C IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: 2026 Jun Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1950-6007 Numbering: – Type: volume Value: 199 Titles: – TitleFull: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Type: main |
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