Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles.

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Title: Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles.
Authors: Billmann M; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA; Institute of Human Genetics, School of Medicine and University Hospital Bonn, University of Bonn, Bonn, Germany., Costanzo M; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Zhang X; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA., Hassan AZ; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA., Rahman M; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA., Brown KR; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Chan KS; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Tong AHY; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Pons C; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology, Barcelona, Spain., Ward HN; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA; Graduate Program in Bioinformatics and Computational Biology (BICB), University of Minnesota, Minneapolis, MN, USA., Ross C; Donnelly Centre, University of Toronto, Toronto, ON, Canada., van Leeuwen J; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Aregger M; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Lawson KA; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Mair B; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Roth AF; Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI, USA., Sen NE; Department of Molecular and Cellular Biology, University of Geneva, Geneva, Switzerland., Forster DT; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Tan G; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Mero P; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Masud SN; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Lee Y; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA; Graduate Program in Bioinformatics and Computational Biology (BICB), University of Minnesota, Minneapolis, MN, USA., Aguilera-Uribe M; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Ušaj M; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Almeida SMT; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Aulakh K; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Bhojoo U; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Birkadze S; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Budijono N; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA., Cai X; Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Caumanns JJ; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Chalmers JJ; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Chandrashekhar M; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Chang D; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA., Climie R; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Dasgupta K; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Drazic A; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Biomedicine, University of Bergen, Bergen, Norway., Echenique JIR; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Gacesa R; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Farias AG; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Habsid A; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Horecka I; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Kantautas K; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Ji F; Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Kim DK; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Surgery, McGill University, Cancer Research Program, Research Institute of McGill University Health Centre, Montreal, QC, Canada., Lee SY; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Liang W; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Lim HJ; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Lin K; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA; Graduate Program in Bioinformatics and Computational Biology (BICB), University of Minnesota, Minneapolis, MN, USA., Lu X; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA., Maier M; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A(∗)STAR), Singapore, Singapore., Nami B; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Nixon A; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Mikolajewicz N; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Mokhtaridoost M; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Nedyalkova L; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Rohde T; Institute of Human Genetics, School of Medicine and University Hospital Bonn, University of Bonn, Bonn, Germany., Rodrigues MS; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Soste M; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Schultz E; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA., Wang W; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA., Seetharaman A; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Shuteriqi E; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Sizova O; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Taylor DT; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Institute for Biomedical Engineering, University of Toronto, Toronto, ON, Canada., Tereshchenko M; Department of Biochemistry, University of Toronto, Toronto, ON, Canada., Tieu D; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Turowec J; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Ubhi T; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Biochemistry, University of Toronto, Toronto, ON, Canada., Varland S; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Biomedicine, University of Bergen, Bergen, Norway., Wang KE; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Wang ZY; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Wei J; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Xiao YX; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Maass PG; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Reversade B; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A(∗)STAR), Singapore, Singapore., Brown GW; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Biochemistry, University of Toronto, Toronto, ON, Canada., Cravatt BF; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Dixon SJ; Department of Biology, Stanford University, Stanford, CA, USA., Wyatt HDM; Department of Biochemistry, University of Toronto, Toronto, ON, Canada., Röst HL; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Roth FP; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Xia T; School of Software Engineering, Huazhong University of Science and Technology, Wuhan, China., Bader GD; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Loewith R; Department of Molecular and Cellular Biology, University of Geneva, Geneva, Switzerland., Davis NG; Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI, USA., Andrews B; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Electronic address: brenda.andrews@utoronto.ca., Myers CL; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA; Graduate Program in Bioinformatics and Computational Biology (BICB), University of Minnesota, Minneapolis, MN, USA. Electronic address: chadm@umn.edu., Moffat J; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Institute for Biomedical Engineering, University of Toronto, Toronto, ON, Canada. Electronic address: jason.moffat@sickkids.ca., Boone C; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan; Canadian Institute for Advanced Research (CIFAR), Toronto, ON, Canada. Electronic address: charlie.boone@utoronto.ca.
Source: Cell [Cell] 2026 Jun 11; Vol. 189 (12), pp. 3736-3759.e58. Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4172
DOI:10.1016/j.cell.2026.03.044