Metabolic adaptation to IMMT deficiency through the ATF6-PPARγ axis is contingent on TP53 mutation status in breast cancer.

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Title: Metabolic adaptation to IMMT deficiency through the ATF6-PPARγ axis is contingent on TP53 mutation status in breast cancer.
Authors: Liu L; Department of General Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.; Department of Thyroid and Breast Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China., Li D; Department of General Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.; Department of General Surgery, The Second Affiliated Hospital of ZunYi Medical University, Zunyi, Guizhou, China., Hou Z; Department of General Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.; Department of Thyroid and Breast Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China., Huang Y; Department of General Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.; Department of Thyroid and Breast Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China., Wang J; Department of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China., Pu C; Department of General Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.; Department of Thyroid and Breast Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China., Zhao Q; Department of General Surgery, The Second Affiliated Hospital of ZunYi Medical University, Zunyi, Guizhou, China., Yu Y; Department of Laboratory Medicine, Nanchuan District People's Hospital, Chongqing, China., Chen R; Department of General Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China. chenrui1983105@163.com.; Department of Thyroid and Breast Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China. chenrui1983105@163.com.
Source: Cell death & disease [Cell Death Dis] 2026 Apr 28; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-4889
DOI:10.1038/s41419-026-08813-y