Trans-eQTLs reveal the architecture of human gene regulatory networks.

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Title: Trans-eQTLs reveal the architecture of human gene regulatory networks.
Authors: Warmerdam CAR; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Westra HJ; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., van der Graaf A; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Bonder MJ; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Deelen P; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., van Lieshout T; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Landman AJ; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Jesse M; Institute of Computer Science, University of Tartu, Tartu, Estonia., Strober BJ; Computational Health Informatics Program, Boston Children's Hospital, Boston, MA, USA., Boltz T; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Lapinska S; Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA., Nagpal S; Center for Integrative Genomics, Georgia Institute of Technology, Atlanta, GA, USA., Xie M; Center for Integrative Genomics, Georgia Institute of Technology, Atlanta, GA, USA., Tay D; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore., Kirsten H; LIFE - Leipzig Research Center for Civilization Diseases, Leipzig University, Leipzig, Germany.; Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, Germany., Naeem H; Sidra Medicine, Doha, Qatar., Raghavan V; Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, Germany., Farzeen A; Institute of Neurogenomics, Computational Health Center, Helmholtz Munich, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Teumer A; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Bialystok, Poland., Favé MJ; Concordia University, Centre for Functional and Structural Genomics, Biology department, Montreal, Canada.; Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Persyn E; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Tokolyi A; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Pool R; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health research institute, Amsterdam, the Netherlands., Hottenga JJ; Neurological Disorder Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha P.O. Box 5825, Qatar.; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Rodríguez RD; Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research, Granada, Spain., Rivas-Torrubia M; Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research, Granada, Spain., Mishra BH; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland., Pierce B; Biological Sciences Division, Public Health Sciences, University of Chicago, Chicago, IL, USA., Tong L; Biological Sciences Division, Public Health Sciences, University of Chicago, Chicago, IL, USA., Wang QS; Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Hasegawa T; M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan., Chhetri SB; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.; Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA., Dutta D; Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, MD, USA., Weiss S; Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17475, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany., Dupuis T; Population Health and Genomics, University of Dundee, Dundee, Scotland, UK., Lyytikäinen LP; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland., Mishra PP; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland., Wood AR; College of Medicine and Health, University of Exeter, Exeter, UK., Burnham KL; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Wen J; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Cheruiyot E; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia., Boahen CK; Department of Internal Medicine and Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands.; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands., Jansen R; Department of Psychiatry, Amsterdam Public Health (Mental Health program) and Amsterdam Neuroscience (Mood, Anxiety, Psychosis, Stress and Sleep Program) Research Institutes, Amsterdam UMC Location Vrije University Amsterdam, Amsterdam, Netherlands., Krohn K; Medical Faculty, University of Leipzig, Leipzig, Germany., Thiery J; LIFE - Leipzig Research Center for Civilization Diseases, Leipzig University, Leipzig, Germany.; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig Medical Center, Leipzig, Germany., Daida K; Integrative Neurogenomics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Department of Neurology, Faculty of Medicine, Juntendo University, Tokyo, Japan., Gibbs JR; Computational Biology Group, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Verlouw J; Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Kukushkina V; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Budde J; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Johnson M; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Sanford J; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Slagboom E; Section of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands., Beutner F; Department of Internal Medicine/Cardiology, Heart Center Leipzig at Leipzig University, Leipzig, Germany., Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, Germany.; LIFE - Leipzig Research Center for Civilization Diseases, Leipzig University, Leipzig, Germany., Martin J; Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), Granada, Spain., Raitoharju E; Molecular Epidemiology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Tampere University Hospital, Tampere, Finland., Kibriya MG; Biological Sciences Division, Public Health Sciences, University of Chicago, Chicago, IL, USA., Jasmine F; Biological Sciences Division, Public Health Sciences, University of Chicago, Chicago, IL, USA., Nauck M; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., Souto JC; Unit of Genomics of Complex Diseases, Institut de Recerca Sant Pau (IR Sant Pau), Sant Quintí 77-79, 08041 Barcelona, Spain., Martinez-Perez A; Unit of Genomics of Complex Diseases, Institut de Recerca Sant Pau (IR Sant Pau), Sant Quintí 77-79, 08041 Barcelona, Spain.; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain., Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Mykkänen J; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Pahkala K; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Paavo Nurmi Centre & Sports and Exercise Medicine, University of Turku, Turku, Finland., Rovio SP; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Public Health, University of Turku and Turku University Hospital, Turku, Finland., Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., van Greevenbroek M; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.; Department of Internal Medicine, Maastricht University Medical Center, Maastricht, the Netherlands., van der Kallen CJH; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.; Department of Internal Medicine, Maastricht University Medical Center, Maastricht, the Netherlands., Schalkwijk CG; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.; Department of Internal Medicine, Maastricht University Medical Center, Maastricht, the Netherlands., Veldink J; Department of Neurology, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, the Netherlands., Freimann K; Institute of Computer Science, University of Tartu, Tartu, Estonia., Vochteloo M; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Kooijmans A; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Ouadah L; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Claringbould A; Department of Internal Medicine, Erasmus MC, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands., Huang Y; Biomarkers and Systems Biology, Research, Biogen, Cambridge, MA, USA., Bryois J; Computational Sciences Center of Excellence, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Tsai EA; Biomarkers and Systems Biology, Research, Biogen, Cambridge, MA, USA., Heinig M; Institute of Computational Biology, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany.; Department of Computer Science, TUM School of Computation, Information and Technology, Technical University of Munich, Garching, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., van der Wijst MGP; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Kumar V; Department of Internal Medicine and Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands.; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands.; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Nitte (Deemed to Be University), Medical Sciences Complex, Nitte University Centre for Science Education and Research (NUCSER), Deralakatte, Mangalore, 575018, India., Visscher PM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia., McRae AF; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia., Montgomery GW; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia., Li Y; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Knight JC; Centre for Human Genetics, University of Oxford, Oxford, UK., Singleton A; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Ferrucci L; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Frayling TM; Department of Genetic Medicine and Development, CMU, University of Geneva., Brown A; Population Health and Genomics, University of Dundee, Dundee, Scotland, UK.; Population Health and Genomics, University of Dundee, Dundee, Scotland, UK., Soria JM; Unit of Genomics of Complex Diseases, Institut de Recerca Sant Pau (IR Sant Pau), Sant Quintí 77-79, 08041 Barcelona, Spain.; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain., Völker U; Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17475, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany., Battle A; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA.; Department of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA., Okada Y; Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.; Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), Osaka University, Suita, Japan., Fukunaga K; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan., Namkoong H; Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan., Ahsan H; Biological Sciences Division, Institute for Population and Precision Health (IPPH), University of Chicago, Chicago, IL, USA., Lehtimäki T; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland., Kähönen M; Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Physiology, Tampere University Hospital, Tampere Finland., Raitakari OT; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; InFLAMES Research Flagship, University of Turku, Turku, Finland., Alarcón-Riquelme ME; Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research, Granada, Spain.; Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden., Barturen G; Department of Genetics, Faculty of Science, University of Granada, 18071 Granada, Spain.; Bioinformatics Laboratory, Biotechnology Institute, Centro de Investigación Biomédica, PTS, Avda. del Conocimiento s/n, 18100 Granada, Spain.; Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research, Granada, Spain., Penninx BWJH; Department of Psychiatry, Amsterdam Public Health (Mental Health program) and Amsterdam Neuroscience (Mood, Anxiety, Psychosis, Stress and Sleep Program) Research Institutes, Amsterdam UMC Location Vrije University Amsterdam, Amsterdam, Netherlands., Paul DS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Inouye M; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK., Awadalla P; Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Sung YJ; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, United States.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States.; Dominantly Inherited Alzheimer Disease Network (DIAN)., van Meurs J; Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Department of Orthopaedics and Sportsmedicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Prokisch H; School of Medicine, Institute of Human Genetics, Technical University of Munich, Munich, Germany.; Institute of Neurogenomics, Computational Health Center, Helmholtz Munich, Neuherberg, Germany.; German Center for Child and Adolescent Health (DZKJ), partner site Munich, Munich, Germany., Peters A; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Chair of Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Blauwendraat C; Integrative Neurogenomics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Mokrab Y; Sidra Medicine, Doha, Qatar.; Department of Biomedical Science, College of Health Sciences, Qatar University, Doha, Qatar.; Department of Genetic Medicine, Weill Cornell Medicine, Qatar., Davenport EE; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, Germany.; LIFE - Leipzig Research Center for Civilization Diseases, Leipzig University, Leipzig, Germany., Loh M; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; National Skin Centre, Research Division, Singapore.; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, United Kingdom., Chambers J; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Precision Health Research (PRECISE), Singapore.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, United Kingdom., Gibson G; Center for Integrative Genomics, Georgia Institute of Technology, Atlanta, GA, USA., Boomsma DI; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, the Netherlands.; Amsterdam Public Health research institute, Amsterdam, the Netherlands.; Amsterdam Reproduction and Development (AR&D) Research Institute, Amsterdam, the Netherlands., Viñuela A; Biosciences Institute, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK.; Population Health and Genomics, University of Dundee, Dundee, Scotland, UK., Pasaniuc B; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ophoff R; Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA., Price AL; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Alasoo K; Institute of Computer Science, University of Tartu, Tartu, Estonia., Kutalik Z; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; University Center for Primary Care and Public Health, Lausanne, Switzerland., Esko T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Franke LH; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Võsa U; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Corporate Authors: IMI DIRECT Consortium, PRECISESADS Clinical Consortium, HELIOS Study Team, Estonian Biobank Research Team, sc-eQTLGen Consortium
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Feb 05. Date of Electronic Publication: 2026 Feb 05.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
DOI:10.64898/2026.02.04.26343575