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Clinical cure of chronic hepatitis B is associated with priming and perpetuation of hepatic CD4+ T cell responses.

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Title: Clinical cure of chronic hepatitis B is associated with priming and perpetuation of hepatic CD4+ T cell responses.
Authors: Jespersen JM; Department of Medicine, Division of Gastroenterology, University of California San Francisco, San Francisco, CA 94143, USA.; UCSF Liver Center, University of California San Francisco, San Francisco, CA 94143, USA., Avanesyan L; Department of Medicine, Division of Gastroenterology, University of California San Francisco, San Francisco, CA 94143, USA.; Division of General and Transplant Hepatology, California Pacific Medical Center and Research Institute, San Francisco, CA 94115, USA., Publicover J; Department of Medicine, Division of Gastroenterology, University of California San Francisco, San Francisco, CA 94143, USA.; UCSF Liver Center, University of California San Francisco, San Francisco, CA 94143, USA., Carey ND; Department of Medicine, Division of Gastroenterology, University of California San Francisco, San Francisco, CA 94143, USA.; UCSF CoLabs Initiative, University of California San Francisco, San Francisco, CA 94143, USA., Patel RK; UCSF CoLabs Initiative, University of California San Francisco, San Francisco, CA 94143, USA., Edwards AW; UCSF CoLabs Initiative, University of California San Francisco, San Francisco, CA 94143, USA., Stenske S; Department of Medicine, Division of Gastroenterology, University of California San Francisco, San Francisco, CA 94143, USA., Shin J; Department of Medicine, Division of Gastroenterology, University of California San Francisco, San Francisco, CA 94143, USA.; Division of General and Transplant Hepatology, California Pacific Medical Center and Research Institute, San Francisco, CA 94115, USA., Li J; Department of Medicine, Division of Gastroenterology, University of California San Francisco, San Francisco, CA 94143, USA.; Division of General and Transplant Hepatology, California Pacific Medical Center and Research Institute, San Francisco, CA 94115, USA., Simone M; Department of Medicine, Division of Gastroenterology, University of California San Francisco, San Francisco, CA 94143, USA., Chew NW; UCSF CoLabs Initiative, University of California San Francisco, San Francisco, CA 94143, USA., Wong N; Department of Medicine, Division of Gastroenterology, University of California San Francisco, San Francisco, CA 94143, USA., Trilok S; Department of Medicine, Division of Gastroenterology, University of California San Francisco, San Francisco, CA 94143, USA., Erickson A; Division of General and Transplant Hepatology, California Pacific Medical Center and Research Institute, San Francisco, CA 94115, USA., Rao A; UCSF CoLabs Initiative, University of California San Francisco, San Francisco, CA 94143, USA., Loo CP; UCSF CoLabs Initiative, University of California San Francisco, San Francisco, CA 94143, USA., Stec M; Abbott Diagnostics, Abbott Park, IL 60064, USA., Anderson M; Abbott Diagnostics, Abbott Park, IL 60064, USA., Cloherty G; Abbott Diagnostics, Abbott Park, IL 60064, USA., Sarkar M; Department of Medicine, Division of Gastroenterology, University of California San Francisco, San Francisco, CA 94143, USA.; UCSF Liver Center, University of California San Francisco, San Francisco, CA 94143, USA., Nishimura SL; UCSF Liver Center, University of California San Francisco, San Francisco, CA 94143, USA.; Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA., Combes AJ; Department of Medicine, Division of Gastroenterology, University of California San Francisco, San Francisco, CA 94143, USA.; UCSF CoLabs Initiative, University of California San Francisco, San Francisco, CA 94143, USA.; Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA.; UCSF Bakar ImmunoX Initiative, University of California San Francisco, San Francisco, CA 94143, USA., Wakil AE; UCSF Liver Center, University of California San Francisco, San Francisco, CA 94143, USA.; Division of General and Transplant Hepatology, California Pacific Medical Center and Research Institute, San Francisco, CA 94115, USA., Segal MR; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94143, USA., Fragiadakis GK; UCSF CoLabs Initiative, University of California San Francisco, San Francisco, CA 94143, USA.; Department of Medicine, Division of Rheumatology, University of California San Francisco, San Francisco, CA 94143, USA., Cooper SL; UCSF Liver Center, University of California San Francisco, San Francisco, CA 94143, USA.; Division of General and Transplant Hepatology, California Pacific Medical Center and Research Institute, San Francisco, CA 94115, USA., Baron JL; Department of Medicine, Division of Gastroenterology, University of California San Francisco, San Francisco, CA 94143, USA.; UCSF Liver Center, University of California San Francisco, San Francisco, CA 94143, USA.
Source: Science translational medicine [Sci Transl Med] 2026 Apr 29; Vol. 18 (847), pp. eadx1523. Date of Electronic Publication: 2026 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.adx1523