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Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer's Disease Models.

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Title: Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer's Disease Models.
Authors: Jesudason CD; Lgenia, Fortville, Indiana 46040, United States., Rangel-Barajas C; Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States., Beach CJ; Indiana University School of Medicine, Indianapolis, Indiana 46202, United States., Beck DE; Purdue University, West Lafayette, Indiana 47907, United States., Caballero-Floran IH; Indiana University School of Medicine, Indianapolis, Indiana 46202, United States., Clayton WB; Indiana University School of Medicine, Indianapolis, Indiana 46202, United States., Da Silva L; Indiana University School of Medicine, Indianapolis, Indiana 46202, United States., David JC; Baker Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia., Doolen S; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, United States., Faulkner AN; Baker Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia., Hamdani AK; Purdue University, West Lafayette, Indiana 47907, United States., Huhe H; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, United States., Huynh K; Baker Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.; La Trobe University, Melbourne, Victoria 3086, Australia., Imhoff RD; Indiana University School of Medicine, Indianapolis, Indiana 46202, United States., Javens-Wolfe J; Indiana Biosciences Research Institute, Indianapolis, Indiana 46202, United States., Mason ER; Indiana University School of Medicine, Indianapolis, Indiana 46202, United States., Moussaif M; Indiana Biosciences Research Institute, Indianapolis, Indiana 46202, United States., Singhal K; Purdue University, West Lafayette, Indiana 47907, United States., Soni DM; Indiana University School of Medicine, Indianapolis, Indiana 46202, United States., van Buuren-Milne M; Baker Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia., Williams SP; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, United States., Angus SP; Indiana University School of Medicine, Indianapolis, Indiana 46202, United States., Chu S; Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States., Dage JL; Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States., Hipskind PA; Lgenia, Fortville, Indiana 46040, United States., Johnson TS; Indiana University School of Medicine, Indianapolis, Indiana 46202, United States., Kaddurah-Daouk R; Duke Institute for Brain Sciences, Duke University, Durham, North Carolina 27708, United States., Lamb BT; Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States., Meikle PJ; Baker Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.; La Trobe University, Melbourne, Victoria 3086, Australia., Mesecar AD; Purdue University, West Lafayette, Indiana 47907, United States., Palkowitz AD; Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.; Indiana Biosciences Research Institute, Indianapolis, Indiana 46202, United States., Quinney SK; Indiana University School of Medicine, Indianapolis, Indiana 46202, United States., Sukoff Rizzo SJ; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, United States., Oblak AL; Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States., Richardson TI; Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.; Indiana Biosciences Research Institute, Indianapolis, Indiana 46202, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2026 May 14; Vol. 69 (9), pp. 10734-10763. Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 May 14; Vol. 69 (9), pp. 10734-10763. <i>Date of Electronic Publication: </i>2026 Apr 30.
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        Value: 10.1021/acs.jmedchem.6c00010
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