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Complement factor H supplementation rather than complete C3 knockout provides therapeutic benefits in IgA nephropathy.

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Title: Complement factor H supplementation rather than complete C3 knockout provides therapeutic benefits in IgA nephropathy.
Authors: Li X; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Ni X; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Yuan X; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Wu H; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Shi S; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Liu L; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Lv J; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Zhang H; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Zhu L; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China. funnyzhuli@bjmu.edu.cn.; Peking University Institute of Nephrology, Beijing, 100034, China. funnyzhuli@bjmu.edu.cn.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China. funnyzhuli@bjmu.edu.cn.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China. funnyzhuli@bjmu.edu.cn.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China. funnyzhuli@bjmu.edu.cn.
Source: Molecular biomedicine [Mol Biomed] 2026 Apr 30; Vol. 7 (1). Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:2662-8651
DOI:10.1186/s43556-026-00463-y