Complement factor H supplementation rather than complete C3 knockout provides therapeutic benefits in IgA nephropathy.
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| Title: | Complement factor H supplementation rather than complete C3 knockout provides therapeutic benefits in IgA nephropathy. |
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| Authors: | Li X; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Ni X; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Yuan X; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Wu H; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Shi S; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Liu L; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Lv J; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Zhang H; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Zhu L; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China. funnyzhuli@bjmu.edu.cn.; Peking University Institute of Nephrology, Beijing, 100034, China. funnyzhuli@bjmu.edu.cn.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China. funnyzhuli@bjmu.edu.cn.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China. funnyzhuli@bjmu.edu.cn.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China. funnyzhuli@bjmu.edu.cn. |
| Source: | Molecular biomedicine [Mol Biomed] 2026 Apr 30; Vol. 7 (1). Date of Electronic Publication: 2026 Apr 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42060028 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Complement factor H supplementation rather than complete C3 knockout provides therapeutic benefits in IgA nephropathy. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Ni+X%22">Ni X</searchLink>; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Yuan+X%22">Yuan X</searchLink>; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wu+H%22">Wu H</searchLink>; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Shi+S%22">Shi S</searchLink>; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Lv+J%22">Lv J</searchLink>; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhu+L%22">Zhu L</searchLink>; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China. funnyzhuli@bjmu.edu.cn.; Peking University Institute of Nephrology, Beijing, 100034, China. funnyzhuli@bjmu.edu.cn.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China. funnyzhuli@bjmu.edu.cn.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China. funnyzhuli@bjmu.edu.cn.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China. funnyzhuli@bjmu.edu.cn. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229918283581406676%22">Molecular biomedicine</searchLink> [Mol Biomed] 2026 Apr 30; Vol. 7 (1). <i>Date of Electronic Publication: </i>2026 Apr 30. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Singapore%22">Springer Singapore </searchLink><i>Country of Publication: </i>Singapore <i>NLM ID: </i>9918283581406676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2662-8651 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226628651%22">26628651 </searchLink><i>NLM ISO Abbreviation: </i>Mol Biomed <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42060028 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s43556-026-00463-y Languages: – Code: eng Text: English Titles: – TitleFull: Complement factor H supplementation rather than complete C3 knockout provides therapeutic benefits in IgA nephropathy. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Li X – PersonEntity: Name: NameFull: Ni X – PersonEntity: Name: NameFull: Yuan X – PersonEntity: Name: NameFull: Wu H – PersonEntity: Name: NameFull: Shi S – PersonEntity: Name: NameFull: Liu L – PersonEntity: Name: NameFull: Lv J – PersonEntity: Name: NameFull: Zhang H – PersonEntity: Name: NameFull: Zhu L IsPartOfRelationships: – BibEntity: Dates: – D: 30 M: 04 Text: 2026 Apr 30 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2662-8651 Numbering: – Type: volume Value: 7 – Type: issue Value: 1 Titles: – TitleFull: Molecular biomedicine Type: main |
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