Remote mobilization of gut Tregs exosomes serves as nanoshuttles for targeted cardioprotection against ischemia/reperfusion injury by ginseng polysaccharides.

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Title: Remote mobilization of gut Tregs exosomes serves as nanoshuttles for targeted cardioprotection against ischemia/reperfusion injury by ginseng polysaccharides.
Authors: Li YY; Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), Guangzhou University of Chinese Medicine, Guangdong- Macao In-Depth Cooperation Zone in Hengqin, 519000, PR China; State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China., Sun L; School of Life Sciences, Northeast Normal University, Changchun 130000, PR China., Wang Y; Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), Guangzhou University of Chinese Medicine, Guangdong- Macao In-Depth Cooperation Zone in Hengqin, 519000, PR China., Yang HY; The Affiliated Dongguan Songshan Lake Central Hospital, Cardiometabolic disease innovation Center, Guangdong Medical University, Dongguan 523326, PR China., Xu DS; Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), Guangzhou University of Chinese Medicine, Guangdong- Macao In-Depth Cooperation Zone in Hengqin, 519000, PR China., Zhong YZ; State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China., Zhang JH; College of Life Science, Northwest Normal University, Lanzhou 730070, PR China., Li Y; Department of Cardiology, General Hospital of Northern Theater Command, Shenyang 110000, PR China., Pi FC; State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China., Li QL; State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China., Li ZR; State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China., Wang WT; State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China., Chen MT; Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), Guangzhou University of Chinese Medicine, Guangdong- Macao In-Depth Cooperation Zone in Hengqin, 519000, PR China; State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China; Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen 518000, PR China., Liu MN; National Traditional Chinese Medicine Clinical Research Base and Department of Cardiovascular Medicine, the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou 646000, PR China., Sun QD; Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), Guangzhou University of Chinese Medicine, Guangdong- Macao In-Depth Cooperation Zone in Hengqin, 519000, PR China; State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China., Peng MM; State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China., Leung EL; Cancer Center, Faculty of Health Sciences, Ministry of Education (MOE) Frontiers Science Center for Precision Oncology, University of Macau, Macao., Wu QB; Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa 999078, Macao. Electronic address: qbwu@must.edu.mo., Han YL; Department of Cardiology, General Hospital of Northern Theater Command, Shenyang 110000, PR China. Electronic address: hanyaling@263.net., Liu L; Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), Guangzhou University of Chinese Medicine, Guangdong- Macao In-Depth Cooperation Zone in Hengqin, 519000, PR China; State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China. Electronic address: lliu@must.edu.mo., Xie Y; Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), Guangzhou University of Chinese Medicine, Guangdong- Macao In-Depth Cooperation Zone in Hengqin, 519000, PR China; State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China. Electronic address: leoxieying16@outlook.com., Zhou YF; School of Life Sciences, Northeast Normal University, Changchun 130000, PR China. Electronic address: zhouyf383@nenu.edu.cn., Zhou H; Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), Guangzhou University of Chinese Medicine, Guangdong- Macao In-Depth Cooperation Zone in Hengqin, 519000, PR China; State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China. Electronic address: gutcmzhs@hotmail.com.
Source: Pharmacological research [Pharmacol Res] 2026 Jun; Vol. 228, pp. 108217. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1096-1186
DOI:10.1016/j.phrs.2026.108217