Admixture-informed polygenic risk reporting using the ePRS framework.

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Title: Admixture-informed polygenic risk reporting using the ePRS framework.
Authors: Huang YJ; Department of Medicine, Harvard Medical School, Boston, MA, USA.; CardioVascular Institute (CVI), Beth Israel Deaconess Medical Center, Boston, MA, USA., Kurniansyah N; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Goodman MO; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Spitzer BW; CardioVascular Institute (CVI), Beth Israel Deaconess Medical Center, Boston, MA, USA., Wang J; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Stilp A; Department of Biostatistics, University of Washington, Seattle, WA, USA., Laurie C; Department of Biostatistics, University of Washington, Seattle, WA, USA., de Vries PS; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Chen H; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Min YI; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Sims M; Department of Social Medicine, Population and Public Health, University of California at Riverside School of Medicine, Riverside, CA, USA., Peloso GM; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rich SS; Department of Genome Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA., Redline S; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Fornage M; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Kaplan R; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Franceschini N; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Levy D; The Population Sciences Branch of the National Heart, Lung and Blood Institute, Bethesda, MD, USA.; The Framingham Heart Study, Framingham, MA, USA., Morrison AC; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Smith NL; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA, USA., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Zöllner S; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Sofer T; Department of Medicine, Harvard Medical School, Boston, MA, USA. tsofer@bidmc.harvard.edu.; CardioVascular Institute (CVI), Beth Israel Deaconess Medical Center, Boston, MA, USA. tsofer@bidmc.harvard.edu.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. tsofer@bidmc.harvard.edu.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. tsofer@bidmc.harvard.edu.
Corporate Authors: Trans-Omics for Precision Medicine Consortium
Source: Nature communications [Nat Commun] 2026 Apr 30. Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-72457-x