Creating highly active fluoroacetate dehalogenases via gate-based synergetic chain design.

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Title: Creating highly active fluoroacetate dehalogenases via gate-based synergetic chain design.
Authors: Wang CZ; Key Laboratory of Multiple Organ Failure (Zhejiang University), Ministry of Education, Department of General Intensive Care Unit of the Second Affiliated Hospital (Zhejiang University), Zhejiang University School of Medicine, Hangzhou, P. R. China.; Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education) and Key Laboratory of Phytochemistry R&D of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, P. R. China.; Guangxi Key Laboratory of Urban Water Environment, College of Chemistry and Environmental Engineering, Baise University, Baise, P. R. China., Huang H; State Key Laboratory of Bioactive Molecules and Draggability Assessment, Pharmacy College, Jinan University, Guangzhou, P. R. China., Hu Z; Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education) and Key Laboratory of Phytochemistry R&D of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, P. R. China., Gao L; Key Laboratory of Multiple Organ Failure (Zhejiang University), Ministry of Education, Department of General Intensive Care Unit of the Second Affiliated Hospital (Zhejiang University), Zhejiang University School of Medicine, Hangzhou, P. R. China., Lin ZQ; Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education) and Key Laboratory of Phytochemistry R&D of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, P. R. China., Shi M; Key Laboratory of Multiple Organ Failure (Zhejiang University), Ministry of Education, Department of General Intensive Care Unit of the Second Affiliated Hospital (Zhejiang University), Zhejiang University School of Medicine, Hangzhou, P. R. China., Song Z; Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education) and Key Laboratory of Phytochemistry R&D of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, P. R. China., Li M; Key Laboratory of Tea Science of Ministry of Education, College of Horticulture, Hunan Agricultural University, Changsha, P. R. China., Wang Y; Key Laboratory of Multiple Organ Failure (Zhejiang University), Ministry of Education, Department of General Intensive Care Unit of the Second Affiliated Hospital (Zhejiang University), Zhejiang University School of Medicine, Hangzhou, P. R. China.; Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education) and Key Laboratory of Phytochemistry R&D of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, P. R. China., Chen KW; Lab of Computational Chemistry and Drug Design, State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen, P. R. China., Liu Y; College of Life Sciences, Zhejiang University, Hangzhou, P. R. China., Ma Y; Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education) and Key Laboratory of Phytochemistry R&D of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, P. R. China., Chen B; Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education) and Key Laboratory of Phytochemistry R&D of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, P. R. China., Yan Q; Hunan Provincial Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University, Changsha, Hunan, P. R. China. yqp-chembio@qq.com.; Greater Bay Area Institute for Innovation, Hunan University, Guangzhou, Guangdong, P. R. China. yqp-chembio@qq.com., Zhang ZM; State Key Laboratory of Bioactive Molecules and Draggability Assessment, Pharmacy College, Jinan University, Guangzhou, P. R. China. zhangzm@jnu.edu.cn., Wang JB; Key Laboratory of Multiple Organ Failure (Zhejiang University), Ministry of Education, Department of General Intensive Care Unit of the Second Affiliated Hospital (Zhejiang University), Zhejiang University School of Medicine, Hangzhou, P. R. China. jwang2023@zju.edu.cn.
Source: Nature communications [Nat Commun] 2026 Apr 30. Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-72741-w