Tick saliva reprograms macrophages into immunosuppressive hubs that regulate T-cell immunity in Rhipicephalus microplus infestation.
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| Title: | Tick saliva reprograms macrophages into immunosuppressive hubs that regulate T-cell immunity in Rhipicephalus microplus infestation. |
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| Authors: | Nakamura H; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan., Okagawa T; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Business Development Unit, FASMAC Co., Ltd., Atsugi, Japan., Maekawa N; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan., Parizi LF; Centro de Biotecnologia and Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Ikehata M; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan., Tiyamanee W; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan., Win SY; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan., Takeuchi H; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan., Maezono K; Laboratory of Public Health, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Veterinary Research Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan., Thammahakin P; Laboratory of Public Health, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan., Kobayashi S; Laboratory of Public Health, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Veterinary Research Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Japan.; One Health Research Center, Hokkaido University, Sapporo, Japan., Fukuta M; Department of Viral Ecology, National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki, Japan., Hirano M; Department of Viral Ecology, National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki, Japan., Yoshii K; Department of Viral Ecology, National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki, Japan., Murata S; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Veterinary Research Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan., Ohashi K; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Veterinary Research Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.; International Affairs Office, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan., Logullo C; Laboratório de Bioquímica de Artrópodes Hematófagos, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., da Silva Vaz I Jr; Centro de Biotecnologia and Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Konnai S; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan. konnai@vetmed.hokudai.ac.jp.; Veterinary Research Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan. konnai@vetmed.hokudai.ac.jp.; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Japan. konnai@vetmed.hokudai.ac.jp.; One Health Research Center, Hokkaido University, Sapporo, Japan. konnai@vetmed.hokudai.ac.jp. |
| Source: | Communications biology [Commun Biol] 2026 Apr 30; Vol. 9 (1). Date of Electronic Publication: 2026 Apr 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2399-3642 |
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| DOI: | 10.1038/s42003-026-09981-5 |
