Ion Mobility-Mass Spectrometry and Collision Induced Unfolding Reveal Linker-Payload Effects on Antibody-Drug Conjugate Higher-Order Structure and Stability.
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| Title: | Ion Mobility-Mass Spectrometry and Collision Induced Unfolding Reveal Linker-Payload Effects on Antibody-Drug Conjugate Higher-Order Structure and Stability. |
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| Authors: | Makey DM; Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.; Analytical Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Emmert MH; Process Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Hu H; Analytical Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Larson EJ; Analytical Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Appiah-Amponsah E; Analytical Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Regalado EL; Analytical Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Barrientos RC; Analytical Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Ruotolo BT; Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States. |
| Source: | Bioconjugate chemistry [Bioconjug Chem] 2026 May 20; Vol. 37 (5), pp. 942-949. Date of Electronic Publication: 2026 Apr 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42063277 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Ion Mobility-Mass Spectrometry and Collision Induced Unfolding Reveal Linker-Payload Effects on Antibody-Drug Conjugate Higher-Order Structure and Stability. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Makey+DM%22">Makey DM</searchLink>; Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.; Analytical Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States.<br /><searchLink fieldCode="AU" term="%22Emmert+MH%22">Emmert MH</searchLink>; Process Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States.<br /><searchLink fieldCode="AU" term="%22Hu+H%22">Hu H</searchLink>; Analytical Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States.<br /><searchLink fieldCode="AU" term="%22Larson+EJ%22">Larson EJ</searchLink>; Analytical Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States.<br /><searchLink fieldCode="AU" term="%22Appiah-Amponsah+E%22">Appiah-Amponsah E</searchLink>; Analytical Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States.<br /><searchLink fieldCode="AU" term="%22Regalado+EL%22">Regalado EL</searchLink>; Analytical Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States.<br /><searchLink fieldCode="AU" term="%22Barrientos+RC%22">Barrientos RC</searchLink>; Analytical Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States.<br /><searchLink fieldCode="AU" term="%22Ruotolo+BT%22">Ruotolo BT</searchLink>; Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229010319%22">Bioconjugate chemistry</searchLink> [Bioconjug Chem] 2026 May 20; Vol. 37 (5), pp. 942-949. <i>Date of Electronic Publication: </i>2026 Apr 30. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9010319 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4812 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210431802%22">10431802 </searchLink><i>NLM ISO Abbreviation: </i>Bioconjug Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42063277 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/acs.bioconjchem.6c00018 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 942 Titles: – TitleFull: Ion Mobility-Mass Spectrometry and Collision Induced Unfolding Reveal Linker-Payload Effects on Antibody-Drug Conjugate Higher-Order Structure and Stability. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Makey DM – PersonEntity: Name: NameFull: Emmert MH – PersonEntity: Name: NameFull: Hu H – PersonEntity: Name: NameFull: Larson EJ – PersonEntity: Name: NameFull: Appiah-Amponsah E – PersonEntity: Name: NameFull: Regalado EL – PersonEntity: Name: NameFull: Barrientos RC – PersonEntity: Name: NameFull: Ruotolo BT IsPartOfRelationships: – BibEntity: Dates: – D: 20 M: 05 Text: 2026 May 20 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1520-4812 Numbering: – Type: volume Value: 37 – Type: issue Value: 5 Titles: – TitleFull: Bioconjugate chemistry Type: main |
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