Ion Mobility-Mass Spectrometry and Collision Induced Unfolding Reveal Linker-Payload Effects on Antibody-Drug Conjugate Higher-Order Structure and Stability.
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| Title: | Ion Mobility-Mass Spectrometry and Collision Induced Unfolding Reveal Linker-Payload Effects on Antibody-Drug Conjugate Higher-Order Structure and Stability. |
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| Authors: | Makey DM; Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.; Analytical Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Emmert MH; Process Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Hu H; Analytical Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Larson EJ; Analytical Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Appiah-Amponsah E; Analytical Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Regalado EL; Analytical Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Barrientos RC; Analytical Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Ruotolo BT; Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States. |
| Source: | Bioconjugate chemistry [Bioconjug Chem] 2026 May 20; Vol. 37 (5), pp. 942-949. Date of Electronic Publication: 2026 Apr 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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