Enzymatic Access to Norstatines by PLP-Dependent Decarboxylative C-C Bond Formation Involved in Leuhistin Biosynthesis.

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Title: Enzymatic Access to Norstatines by PLP-Dependent Decarboxylative C-C Bond Formation Involved in Leuhistin Biosynthesis.
Authors: Mizutani T; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.; Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Tokyo 113-8657, Japan., Awakawa T; RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan., Adachi N; Life Science Center for Survival Dynamics (TARA), University of Tsukuba, Ibaraki 305-8577, Japan., Yamada Y; International Center for Synchrotron Radiation Innovation Smart (SRIS), Tohoku University, Miyagi 980-8572, Japan., Mori T; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.; Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Tokyo 113-8657, Japan., Abe I; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.; Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Tokyo 113-8657, Japan.; Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
Source: Journal of the American Chemical Society [J Am Chem Soc] 2026 May 13; Vol. 148 (18), pp. 18633-18637. Date of Electronic Publication: 2026 May 01.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-5126
DOI:10.1021/jacs.6c05214