Synthesis, biological evaluation and molecular docking studies of N-propylsulfonyl indole-linked hydrazinecarbothioamides as selective ecto-5'-nucleotidase and NTPDase inhibitors.

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Title: Synthesis, biological evaluation and molecular docking studies of N-propylsulfonyl indole-linked hydrazinecarbothioamides as selective ecto-5'-nucleotidase and NTPDase inhibitors.
Authors: Batool Z; Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan., Dutt SM; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan., Al-Rashida M; Department of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan., Gelsleichter NE; Département de microbiologie-infectiologie et d'immunologie, Centres PROTEO et ARThrite, Faculté de Médecine, Université Laval, Quebec City, QC, G1V 0A6, Canada.; Axe Maladies infectieuses et immunitaires, Centre de recherche du CHU de Québec - Université Laval, Quebec City, QC, G1V 4G2, Canada., Pelletier J; Axe Maladies infectieuses et immunitaires, Centre de recherche du CHU de Québec - Université Laval, Quebec City, QC, G1V 4G2, Canada., Sévigny J; Département de microbiologie-infectiologie et d'immunologie, Centres PROTEO et ARThrite, Faculté de Médecine, Université Laval, Quebec City, QC, G1V 0A6, Canada.; Axe Maladies infectieuses et immunitaires, Centre de recherche du CHU de Québec - Université Laval, Quebec City, QC, G1V 4G2, Canada., Islam T; Department of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan., Ismail MA; Department of Chemistry, Faculty of Science, Research Center for Advanced Materials Science (RCAMS), King Khalid University, P.O. Box 960, Abha, 61421, Saudi Arabia., Khan A; Department of Chemical and Biological Engineering, College of Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. ajmalkhan@unizwa.edu.om.; Natural and Medical Sciences Research Centre, University of Nizwa, P.O. Box 33, PC 616, Birkat Al Mauz, Nizwa, Sultanate of Oman. ajmalkhan@unizwa.edu.om., Şenol H; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Bezmialem Vakif University, 34093, Fatih, İstanbul, Türkiye., Alharthy RD; Department of Chemistry, Rabigh Branch, Science & Arts College, King Abdulaziz University, Rabigh, 21911, Saudi Arabia., Iqbal J; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan. jamshediqb@googlemail.com., Shafiq Z; Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan. zahidshafiq@bzu.edu.pk.
Source: Scientific reports [Sci Rep] 2026 May 02; Vol. 16 (1). Date of Electronic Publication: 2026 May 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2045-2322
DOI:10.1038/s41598-026-50728-3