Synthesis, biological evaluation and molecular docking studies of N-propylsulfonyl indole-linked hydrazinecarbothioamides as selective ecto-5'-nucleotidase and NTPDase inhibitors.
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| Title: | Synthesis, biological evaluation and molecular docking studies of N-propylsulfonyl indole-linked hydrazinecarbothioamides as selective ecto-5'-nucleotidase and NTPDase inhibitors. |
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| Authors: | Batool Z; Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan., Dutt SM; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan., Al-Rashida M; Department of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan., Gelsleichter NE; Département de microbiologie-infectiologie et d'immunologie, Centres PROTEO et ARThrite, Faculté de Médecine, Université Laval, Quebec City, QC, G1V 0A6, Canada.; Axe Maladies infectieuses et immunitaires, Centre de recherche du CHU de Québec - Université Laval, Quebec City, QC, G1V 4G2, Canada., Pelletier J; Axe Maladies infectieuses et immunitaires, Centre de recherche du CHU de Québec - Université Laval, Quebec City, QC, G1V 4G2, Canada., Sévigny J; Département de microbiologie-infectiologie et d'immunologie, Centres PROTEO et ARThrite, Faculté de Médecine, Université Laval, Quebec City, QC, G1V 0A6, Canada.; Axe Maladies infectieuses et immunitaires, Centre de recherche du CHU de Québec - Université Laval, Quebec City, QC, G1V 4G2, Canada., Islam T; Department of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan., Ismail MA; Department of Chemistry, Faculty of Science, Research Center for Advanced Materials Science (RCAMS), King Khalid University, P.O. Box 960, Abha, 61421, Saudi Arabia., Khan A; Department of Chemical and Biological Engineering, College of Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. ajmalkhan@unizwa.edu.om.; Natural and Medical Sciences Research Centre, University of Nizwa, P.O. Box 33, PC 616, Birkat Al Mauz, Nizwa, Sultanate of Oman. ajmalkhan@unizwa.edu.om., Şenol H; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Bezmialem Vakif University, 34093, Fatih, İstanbul, Türkiye., Alharthy RD; Department of Chemistry, Rabigh Branch, Science & Arts College, King Abdulaziz University, Rabigh, 21911, Saudi Arabia., Iqbal J; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan. jamshediqb@googlemail.com., Shafiq Z; Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan. zahidshafiq@bzu.edu.pk. |
| Source: | Scientific reports [Sci Rep] 2026 May 02; Vol. 16 (1). Date of Electronic Publication: 2026 May 02. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42069907 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Synthesis, biological evaluation and molecular docking studies of N-propylsulfonyl indole-linked hydrazinecarbothioamides as selective ecto-5'-nucleotidase and NTPDase inhibitors. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Batool+Z%22">Batool Z</searchLink>; Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan.<br /><searchLink fieldCode="AU" term="%22Dutt+SM%22">Dutt SM</searchLink>; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan.<br /><searchLink fieldCode="AU" term="%22Al-Rashida+M%22">Al-Rashida M</searchLink>; Department of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Gelsleichter+NE%22">Gelsleichter NE</searchLink>; Département de microbiologie-infectiologie et d'immunologie, Centres PROTEO et ARThrite, Faculté de Médecine, Université Laval, Quebec City, QC, G1V 0A6, Canada.; Axe Maladies infectieuses et immunitaires, Centre de recherche du CHU de Québec - Université Laval, Quebec City, QC, G1V 4G2, Canada.<br /><searchLink fieldCode="AU" term="%22Pelletier+J%22">Pelletier J</searchLink>; Axe Maladies infectieuses et immunitaires, Centre de recherche du CHU de Québec - Université Laval, Quebec City, QC, G1V 4G2, Canada.<br /><searchLink fieldCode="AU" term="%22Sévigny+J%22">Sévigny J</searchLink>; Département de microbiologie-infectiologie et d'immunologie, Centres PROTEO et ARThrite, Faculté de Médecine, Université Laval, Quebec City, QC, G1V 0A6, Canada.; Axe Maladies infectieuses et immunitaires, Centre de recherche du CHU de Québec - Université Laval, Quebec City, QC, G1V 4G2, Canada.<br /><searchLink fieldCode="AU" term="%22Islam+T%22">Islam T</searchLink>; Department of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Ismail+MA%22">Ismail MA</searchLink>; Department of Chemistry, Faculty of Science, Research Center for Advanced Materials Science (RCAMS), King Khalid University, P.O. Box 960, Abha, 61421, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Khan+A%22">Khan A</searchLink>; Department of Chemical and Biological Engineering, College of Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. ajmalkhan@unizwa.edu.om.; Natural and Medical Sciences Research Centre, University of Nizwa, P.O. Box 33, PC 616, Birkat Al Mauz, Nizwa, Sultanate of Oman. ajmalkhan@unizwa.edu.om.<br /><searchLink fieldCode="AU" term="%22Şenol+H%22">Şenol H</searchLink>; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Bezmialem Vakif University, 34093, Fatih, İstanbul, Türkiye.<br /><searchLink fieldCode="AU" term="%22Alharthy+RD%22">Alharthy RD</searchLink>; Department of Chemistry, Rabigh Branch, Science & Arts College, King Abdulaziz University, Rabigh, 21911, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Iqbal+J%22">Iqbal J</searchLink>; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan. jamshediqb@googlemail.com.<br /><searchLink fieldCode="AU" term="%22Shafiq+Z%22">Shafiq Z</searchLink>; Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan. zahidshafiq@bzu.edu.pk. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 May 02; Vol. 16 (1). <i>Date of Electronic Publication: </i>2026 May 02. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101563288 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2045-2322 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220452322%22">20452322 </searchLink><i>NLM ISO Abbreviation: </i>Sci Rep <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42069907 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41598-026-50728-3 Languages: – Code: eng Text: English Titles: – TitleFull: Synthesis, biological evaluation and molecular docking studies of N-propylsulfonyl indole-linked hydrazinecarbothioamides as selective ecto-5'-nucleotidase and NTPDase inhibitors. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Batool Z – PersonEntity: Name: NameFull: Dutt SM – PersonEntity: Name: NameFull: Al-Rashida M – PersonEntity: Name: NameFull: Gelsleichter NE – PersonEntity: Name: NameFull: Pelletier J – PersonEntity: Name: NameFull: Sévigny J – PersonEntity: Name: NameFull: Islam T – PersonEntity: Name: NameFull: Ismail MA – PersonEntity: Name: NameFull: Khan A – PersonEntity: Name: NameFull: Şenol H – PersonEntity: Name: NameFull: Alharthy RD – PersonEntity: Name: NameFull: Iqbal J – PersonEntity: Name: NameFull: Shafiq Z IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 05 Text: 2026 May 02 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2045-2322 Numbering: – Type: volume Value: 16 – Type: issue Value: 1 Titles: – TitleFull: Scientific reports Type: main |
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