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Bidirectional coupling among EMT, AXL-RB1 signaling and lineage switch drives resistance to osimertinib and worse clinical outcomes in NSCLC.

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Bibliographic Details
Title: Bidirectional coupling among EMT, AXL-RB1 signaling and lineage switch drives resistance to osimertinib and worse clinical outcomes in NSCLC.
Authors: Vashista S; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India., Meena RK; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India.; Undergraduate Program, Indian Institute of Science, Bangalore, 560012, India., Kulkarni P; Department of Medical Oncology & Therapeutics Research, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA., Salgia R; Department of Medical Oncology & Therapeutics Research, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA., Thomas A; Developmental Therapeutics Branch, National Cancer Institute, Bethesda, MD 20892, USA., Jolly MK; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 24. Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.64898/2026.04.21.719547