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Bidirectional coupling among EMT, AXL-RB1 signaling and lineage switch drives resistance to osimertinib and worse clinical outcomes in NSCLC.

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Title: Bidirectional coupling among EMT, AXL-RB1 signaling and lineage switch drives resistance to osimertinib and worse clinical outcomes in NSCLC.
Authors: Vashista S; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India., Meena RK; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India.; Undergraduate Program, Indian Institute of Science, Bangalore, 560012, India., Kulkarni P; Department of Medical Oncology & Therapeutics Research, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA., Salgia R; Department of Medical Oncology & Therapeutics Research, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA., Thomas A; Developmental Therapeutics Branch, National Cancer Institute, Bethesda, MD 20892, USA., Jolly MK; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 24. Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
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AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Bidirectional coupling among EMT, AXL-RB1 signaling and lineage switch drives resistance to osimertinib and worse clinical outcomes in NSCLC.
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  Data: <searchLink fieldCode="AU" term="%22Vashista+S%22">Vashista S</searchLink>; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India.<br /><searchLink fieldCode="AU" term="%22Meena+RK%22">Meena RK</searchLink>; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India.; Undergraduate Program, Indian Institute of Science, Bangalore, 560012, India.<br /><searchLink fieldCode="AU" term="%22Kulkarni+P%22">Kulkarni P</searchLink>; Department of Medical Oncology & Therapeutics Research, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA.<br /><searchLink fieldCode="AU" term="%22Salgia+R%22">Salgia R</searchLink>; Department of Medical Oncology & Therapeutics Research, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA.<br /><searchLink fieldCode="AU" term="%22Thomas+A%22">Thomas A</searchLink>; Developmental Therapeutics Branch, National Cancer Institute, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Jolly+MK%22">Jolly MK</searchLink>; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2026 Apr 24. <i>Date of Electronic Publication: </i>2026 Apr 24.
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42079213
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      – Type: doi
        Value: 10.64898/2026.04.21.719547
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      – Code: eng
        Text: English
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      – TitleFull: Bidirectional coupling among EMT, AXL-RB1 signaling and lineage switch drives resistance to osimertinib and worse clinical outcomes in NSCLC.
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              Text: 2026 Apr 24
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