Bidirectional coupling among EMT, AXL-RB1 signaling and lineage switch drives resistance to osimertinib and worse clinical outcomes in NSCLC.
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| Title: | Bidirectional coupling among EMT, AXL-RB1 signaling and lineage switch drives resistance to osimertinib and worse clinical outcomes in NSCLC. |
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| Authors: | Vashista S; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India., Meena RK; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India.; Undergraduate Program, Indian Institute of Science, Bangalore, 560012, India., Kulkarni P; Department of Medical Oncology & Therapeutics Research, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA., Salgia R; Department of Medical Oncology & Therapeutics Research, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA., Thomas A; Developmental Therapeutics Branch, National Cancer Institute, Bethesda, MD 20892, USA., Jolly MK; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 24. Date of Electronic Publication: 2026 Apr 24. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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