5'tRNA-derived fragments modulate β-cell homeostasis and islet macrophage activation in type 2 diabetes.

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Title: 5'tRNA-derived fragments modulate β-cell homeostasis and islet macrophage activation in type 2 diabetes.
Authors: Cosentino C; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland. cristina.cosentino@unil.ch., Klein R; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland., Menoud V; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland., Guay C; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland., Aiello E; Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy., Auddino S; Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy., Di Giuseppe G; Department of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy., Ciccarelli G; Department of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy., Galli A; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland., Alabiso F; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy., Mangano E; Institute for Biomedical Technologies, National Research Council, Milan, Italy., Brozzi F; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland., Bouzakri K; UMR DIATHEC, EA 7294, Centre Européen d'Etude du Diabète, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France., D'Adamo S; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy., Cetrullo S; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.; Istituto Nazionale per le Ricerche Cardiovascolari, Bologna, Italy.; Health Sciences and Technologies-Interdepartmental Center for Industrial Research (CIRI-SDV), University of Bologna, Bologna, Italy., Quero G; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.; Department of Medical and Surgical Sciences, Digestive Surgery Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Mari A; Institute of Neuroscience, National Research Council, Padua, Italy., Alfieri S; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.; Department of Medical and Surgical Sciences, Digestive Surgery Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Giaccari A; Department of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy., Mezza T; Department of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy., Dotta F; Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy., Sebastiani G; Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy., Regazzi R; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
Source: Nature communications [Nat Commun] 2026 May 04. Date of Electronic Publication: 2026 May 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-72641-z