PRKN/parkin-mediated control of SNCA (synuclein alpha) and chaperone-mediated autophagy are defective in cellular, mice models and Parkinson disease-affected brains.

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Title: PRKN/parkin-mediated control of SNCA (synuclein alpha) and chaperone-mediated autophagy are defective in cellular, mice models and Parkinson disease-affected brains.
Authors: Ramos Dos Santos L; University Côte d'Azur, INSERM, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 'Laboratory of Excellence (LABEX) Distalz', Valbonne, France., Duplan E; University Côte d'Azur, INSERM, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 'Laboratory of Excellence (LABEX) Distalz', Valbonne, France., Debord J; University Côte d'Azur, INSERM, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 'Laboratory of Excellence (LABEX) Distalz', Valbonne, France., Fremont G; University Côte d'Azur, INSERM, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 'Laboratory of Excellence (LABEX) Distalz', Valbonne, France., Minniti J; University Côte d'Azur, INSERM, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 'Laboratory of Excellence (LABEX) Distalz', Valbonne, France., Lauritzen I; University Côte d'Azur, INSERM, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 'Laboratory of Excellence (LABEX) Distalz', Valbonne, France., Mutez E; University of Lille, INSERM, CHU Lille, UMR-S 1172-LilNCog-Lille Neuroscience and Cognition, Lille, France., Leghay C; University of Lille, INSERM, CHU Lille, UMR-S 1172-LilNCog-Lille Neuroscience and Cognition, Lille, France., Chartier-Harlin MC; University of Lille, INSERM, CHU Lille, UMR-S 1172-LilNCog-Lille Neuroscience and Cognition, Lille, France., Checler F; University Côte d'Azur, INSERM, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 'Laboratory of Excellence (LABEX) Distalz', Valbonne, France., Alves da Costa C; University Côte d'Azur, INSERM, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 'Laboratory of Excellence (LABEX) Distalz', Valbonne, France.
Source: Autophagy [Autophagy] 2026 May 13, pp. 1-19. Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101265188 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8635 (Electronic) Linking ISSN: 15548627 NLM ISO Abbreviation: Autophagy Subsets: MEDLINE
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  Data: PRKN/parkin-mediated control of SNCA (synuclein alpha) and chaperone-mediated autophagy are defective in cellular, mice models and Parkinson disease-affected brains.
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  Data: <searchLink fieldCode="AU" term="%22Ramos+Dos+Santos+L%22">Ramos Dos Santos L</searchLink>; University Côte d'Azur, INSERM, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 'Laboratory of Excellence (LABEX) Distalz', Valbonne, France.<br /><searchLink fieldCode="AU" term="%22Duplan+E%22">Duplan E</searchLink>; University Côte d'Azur, INSERM, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 'Laboratory of Excellence (LABEX) Distalz', Valbonne, France.<br /><searchLink fieldCode="AU" term="%22Debord+J%22">Debord J</searchLink>; University Côte d'Azur, INSERM, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 'Laboratory of Excellence (LABEX) Distalz', Valbonne, France.<br /><searchLink fieldCode="AU" term="%22Fremont+G%22">Fremont G</searchLink>; University Côte d'Azur, INSERM, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 'Laboratory of Excellence (LABEX) Distalz', Valbonne, France.<br /><searchLink fieldCode="AU" term="%22Minniti+J%22">Minniti J</searchLink>; University Côte d'Azur, INSERM, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 'Laboratory of Excellence (LABEX) Distalz', Valbonne, France.<br /><searchLink fieldCode="AU" term="%22Lauritzen+I%22">Lauritzen I</searchLink>; University Côte d'Azur, INSERM, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 'Laboratory of Excellence (LABEX) Distalz', Valbonne, France.<br /><searchLink fieldCode="AU" term="%22Mutez+E%22">Mutez E</searchLink>; University of Lille, INSERM, CHU Lille, UMR-S 1172-LilNCog-Lille Neuroscience and Cognition, Lille, France.<br /><searchLink fieldCode="AU" term="%22Leghay+C%22">Leghay C</searchLink>; University of Lille, INSERM, CHU Lille, UMR-S 1172-LilNCog-Lille Neuroscience and Cognition, Lille, France.<br /><searchLink fieldCode="AU" term="%22Chartier-Harlin+MC%22">Chartier-Harlin MC</searchLink>; University of Lille, INSERM, CHU Lille, UMR-S 1172-LilNCog-Lille Neuroscience and Cognition, Lille, France.<br /><searchLink fieldCode="AU" term="%22Checler+F%22">Checler F</searchLink>; University Côte d'Azur, INSERM, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 'Laboratory of Excellence (LABEX) Distalz', Valbonne, France.<br /><searchLink fieldCode="AU" term="%22Alves+da+Costa+C%22">Alves da Costa C</searchLink>; University Côte d'Azur, INSERM, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 'Laboratory of Excellence (LABEX) Distalz', Valbonne, France.
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