In vitro and in vivo preclinical pharmacokinetic characterisation of ulacamten, a small molecule cardiac myosin inhibitor for the treatment of heart failure with preserved ejection fraction (HFpEF).
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| Title: | In vitro and in vivo preclinical pharmacokinetic characterisation of ulacamten, a small molecule cardiac myosin inhibitor for the treatment of heart failure with preserved ejection fraction (HFpEF). |
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| Authors: | Grillo MP; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Zamora J; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Easterday AN; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Azimi M; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Romond RJ; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Morgan BP; Research and Non-Clinical Development, Cytokinetics, Inc, South San Francisco, California, USA., Sukhun R; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA. |
| Source: | Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2026 May; Vol. 56 (5), pp. 365-380. Date of Electronic Publication: 2026 May 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1366-5928 (Electronic) Linking ISSN: 00498254 NLM ISO Abbreviation: Xenobiotica Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1366-5928 |
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| DOI: | 10.1080/00498254.2026.2668393 |
