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Exposure-response modeling of QTc interval and creatine kinase-MB in healthy people and treatment-naïve adults living with HIV-1 treated with ainuovirine monotherapy or combined with lamivudine and tenofovir DF.

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Title: Exposure-response modeling of QTc interval and creatine kinase-MB in healthy people and treatment-naïve adults living with HIV-1 treated with ainuovirine monotherapy or combined with lamivudine and tenofovir DF.
Authors: Zhou Z; Clinical Research and Development Center, Jiangsu Aidea Pharmaceutical Co., Ltd, Yangzhou 225008, Jiangsu Province, China; Chengdu Aidea Pharmaceutical Technology Co., Ltd, Chengdu 610200, Sichuan Province, China., Zhang Y; Beijing Key Laboratory for HIV/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China., Yun X; Clinical Research and Development Center, Jiangsu Aidea Pharmaceutical Co., Ltd, Yangzhou 225008, Jiangsu Province, China., Wu H; Beijing Key Laboratory for HIV/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China., Qin H; Clinical Research and Development Center, Jiangsu Aidea Pharmaceutical Co., Ltd, Yangzhou 225008, Jiangsu Province, China. Electronic address: qinh@aidea.com.cn., Su B; Beijing Key Laboratory for HIV/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China. Electronic address: binsu@ccmu.edu.cn.
Source: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2026 Jul 01; Vol. 222, pp. 107544. Date of Electronic Publication: 2026 May 03.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-0720
DOI:10.1016/j.ejps.2026.107544