Proteasomal-dependent CHK1 degradation leads to DNA damage accumulation in ALS cellular model systems.

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Title: Proteasomal-dependent CHK1 degradation leads to DNA damage accumulation in ALS cellular model systems.
Authors: Modafferi S; Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy., Silenzi V; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy., Garbelli A; Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy., Lazoi G; Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy., Scarian E; Cellular Models and Neuroepigenetics Section, IRCCS Mondino Foundation, Pavia, Italy., D'Uva S; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy., Santini T; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy., Riccardi A; Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy., Cozzolino M; Institute of Translational Pharmacology, CNR, Rome, Italy., Pansarasa O; Cellular Models and Neuroepigenetics Section, IRCCS Mondino Foundation, Pavia, Italy., D'Ambrosi N; Department of Biology, University of Rome Tor Vergata, Rome, Italy., Sabbioneda S; Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy., Morlando M; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy., Francia S; Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy. sofia.francia@cnr.it.
Source: Cell death & disease [Cell Death Dis] 2026 May 06; Vol. 17 (1). Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-4889
DOI:10.1038/s41419-026-08603-6