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Proteasomal-dependent CHK1 degradation leads to DNA damage accumulation in ALS cellular model systems.

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Title: Proteasomal-dependent CHK1 degradation leads to DNA damage accumulation in ALS cellular model systems.
Authors: Modafferi S; Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy., Silenzi V; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy., Garbelli A; Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy., Lazoi G; Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy., Scarian E; Cellular Models and Neuroepigenetics Section, IRCCS Mondino Foundation, Pavia, Italy., D'Uva S; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy., Santini T; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy., Riccardi A; Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy., Cozzolino M; Institute of Translational Pharmacology, CNR, Rome, Italy., Pansarasa O; Cellular Models and Neuroepigenetics Section, IRCCS Mondino Foundation, Pavia, Italy., D'Ambrosi N; Department of Biology, University of Rome Tor Vergata, Rome, Italy., Sabbioneda S; Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy., Morlando M; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy., Francia S; Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy. sofia.francia@cnr.it.
Source: Cell death & disease [Cell Death Dis] 2026 May 06; Vol. 17 (1). Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Proteasomal-dependent CHK1 degradation leads to DNA damage accumulation in ALS cellular model systems.
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  Data: <searchLink fieldCode="AU" term="%22Modafferi+S%22">Modafferi S</searchLink>; Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Silenzi+V%22">Silenzi V</searchLink>; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Garbelli+A%22">Garbelli A</searchLink>; Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Lazoi+G%22">Lazoi G</searchLink>; Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Scarian+E%22">Scarian E</searchLink>; Cellular Models and Neuroepigenetics Section, IRCCS Mondino Foundation, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22D'Uva+S%22">D'Uva S</searchLink>; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Santini+T%22">Santini T</searchLink>; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Riccardi+A%22">Riccardi A</searchLink>; Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Cozzolino+M%22">Cozzolino M</searchLink>; Institute of Translational Pharmacology, CNR, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pansarasa+O%22">Pansarasa O</searchLink>; Cellular Models and Neuroepigenetics Section, IRCCS Mondino Foundation, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22D'Ambrosi+N%22">D'Ambrosi N</searchLink>; Department of Biology, University of Rome Tor Vergata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Sabbioneda+S%22">Sabbioneda S</searchLink>; Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Morlando+M%22">Morlando M</searchLink>; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Francia+S%22">Francia S</searchLink>; Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy. sofia.francia@cnr.it.
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  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 May 06; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 May 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE
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