Phosphorylation tunes p62 condensates to drive autophagic degradation of ubiquitinated proteins.
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| Title: | Phosphorylation tunes p62 condensates to drive autophagic degradation of ubiquitinated proteins. |
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| Authors: | Komatsu-Hirota S; Department of Physiology, Juntendo University Graduate School of Medicine, Tokyo, Japan., Tabata K; Department of Physiology, Juntendo University Graduate School of Medicine, Tokyo, Japan., Sou YS; Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, Tokyo, Japan., Kakuta S; Laboratory of Morphology and Image Analysis, Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Tokyo, Japan., Sakamaki JI; Department of Physiology, Juntendo University Graduate School of Medicine, Tokyo, Japan., Tsuchiya H; Department of Physiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.; Autophagy Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan., Li J; Department of Physiology, Juntendo University Graduate School of Medicine, Tokyo, Japan., Kumeta H; Frontier Research Center for Advanced Material and Life Science, Graduate School of Life Science and Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan., Sakai Y; Graduate School of Nanobioscience, Yokohama City University, Yokohama, Japan., Fujioka Y; Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan., Noshiro D; Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan., Shimobayashi SF; Department of Life Science Frontiers Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan., Kurimura T; Department of Life Science Frontiers Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan., Taniguchi T; Graduate School of Engineering, Department of Chemical Engineering, Kyoto University, Kyoto, Japan., Abe M; Department of Animal Model Development, Brain Research Institute, Niigata University, Niigata, Japan., Koike M; Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, Tokyo, Japan., Morishita H; Department of Molecular Cell Biology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Noda NN; Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan., Komatsu M; Department of Physiology, Juntendo University Graduate School of Medicine, Tokyo, Japan. mkomatsu@juntendo.ac.jp.; Autophagy Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan. mkomatsu@juntendo.ac.jp. |
| Source: | The EMBO journal [EMBO J] 2026 Jun; Vol. 45 (12), pp. 4061-4093. Date of Electronic Publication: 2026 May 05. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1460-2075 |
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| DOI: | 10.1038/s44318-026-00785-1 |
