Multinational validation of the PREVENT and SCORE2 cardiovascular risk equations across 6.4 million individuals.

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Title: Multinational validation of the PREVENT and SCORE2 cardiovascular risk equations across 6.4 million individuals.
Authors: Neuen BL; The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.; Department of Renal Medicine, Royal North Shore Hospital, Sydney, NSW, Australia., Major RW; School of Medical Sciences - Public Health and Epidemiology Division (SAPPHIRE Group) College of Life Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK.; University Hospitals of Leicester NHS Trust Leicester, Leicester, UK.; Leicester, Leicestershire and Rutland Integrated Care Board, Leicester, UK., Grams ME; Division of Precision Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA. ckdpc@nyulangone.org., Sang Y; Optimal Aging Institute, Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA., Coresh J; Optimal Aging Institute, Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA. Josef.Coresh@nyulangone.org., Ballew SH; Optimal Aging Institute, Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA., Surapaneni A; Division of Precision Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA., de Pinho NA; Centre for Research in Epidemiology and Population Health (CESP), Clinical Epidemiology Team, Inserm U1018, Paris-Saclay University, 12 Avenue Paul Vaillant Couturier, Villejuif, France., Arnlov J; Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institute, Stockholm, Sweden., Arnott C; The George Institute for Global Health, University of New South Wales, Sydney, Australia.; Department of Cardiology St Vincent's Hospital, Sydney, Australia.; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia., Bell S; Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK., Berry J; Department of Medicine, UT Tyler School of Medicine, Tyler, TX, USA., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.; Network Aging Research, University of Heidelberg, Heidelberg, Germany., Ciemins E; American Medical Group Association, Virginia, USA., Chang AR; Department of Nephrology, Geisinger, Danville, PA, USA., Cushman M; Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA., de Lemos JA; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA., Diaz-Tocados JM; Vascular and Renal Translational Research Group, Biomedical Research Institute of Lleida, Dr. Pifarré Foundation (IRBLleida), RICORS, Lleida, Spain., Farjat AE; Clinical Statistics & Analytics, Bayer BV, Hoofddorp, Netherlands., Fletcher RA; The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.; Department of Renal Medicine, Royal North Shore Hospital, Sydney, NSW, Australia.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Gansevoort RT; University Medical Centre Groningen, Groningen, Netherlands., Heerspink HJL; Department of Clinical Pharmacy and Pharmacology, University of Groningen, Groningen, The Netherlands., Herrington WG; Renal Studies Group, Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom and Oxford Kidney Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Hong C; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA., Horwitz EJ; Department of Medicine, Division of Nephrology & Hypertension, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Hwang SJ; Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Jassal SK; Department of Medicine, Division of General Internal Medicine, University of California San Diego, San Diego, CA, USA., Kalra PA; Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK., Katz R; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA., Khan SS; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Kovesdy CP; The University of Tennessee Health Science Center College of Medicine, Memphis, TN, USA.; Memphis VA Medical Center, Tennessee, USA., Kronenberg F; Department of Genetics, Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria., Lees JS; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK., Lloyd-Jones DM; Framingham Center for Population and Prevention Science and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA., Mill JG; Department of Physiological Sciences and Cassiano Antonio Moraes University Hospital (Hucam/Ebserh), Federal University of Espírito Santo, Vitória, ES, Brazil., Naimark DMJ; Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Ndumele C; Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Baltimore, MD, USA.; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD, USA., Polkinghorne KR; Department of Nephrology, Monash Medical Centre, Monash Health, Melbourne, Victoria, Australia.; Department of Medicine, Monash University, Melbourne, Victoria, Australia.; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health, University of Washington, Seattle, Washington, USA., Schloemer P; Clinical Statistics & Analytics, Pharmaceuticals, Bayer AG, Berlin, Germany., Shlipak M; Kidney Health Research Collaborative, San Francisco Veterans Affairs Health Care System, University of California, San Francisco, San Francisco, California, USA., Shrestha P; The University of Tennessee Health Science Center College of Medicine, Memphis, TN, USA., Song Z; Department of Public Health and Health Systems, Nagoya University Graduate School of Medicine, Nagoya, Japan., Staplin N; Renal Studies Group, Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom., Steubl D; Boehringer Ingelheim International GmbH, Ingelheim, Germany.; Department of Nephrology, Hospital rechts der Isar, Technical University Munich, Munich, Germany., Vart P; Department of Clinical Pharmacy and Pharmacology, University of Groningen, Groningen, The Netherlands., Visseren FLJ; Department of Vascular Medicine, Utrecht University, Utrecht, The Netherlands., Woodward M; The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.; Department of Renal Medicine, Royal North Shore Hospital, Sydney, NSW, Australia.; The George Institute for Global Health, School of Public Health, Imperial College London, London, United Kingdom., Yamagishi K; Department of Public Health Medicine, Institute of Medicine, and Health Services Research and Development Center, University of Tsukuba, Tsukuba, Japan.; Department of Public Health, Graduate School of Medicine, Juntendo University, Tokyo, Japan., Young BA; Division of Nephrology, University of Washington, Seattle, WA, USA., Sabanayagam C; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore and Duke-NUS Medical School, Singapore, Singapore., Valdivielso JM; Vascular and Renal Translational Research Group, Biomedical Research Institute of Lleida, Dr. Pifarré Foundation (IRBLleida), RICORS, Lleida, Spain.
Source: Nature medicine [Nat Med] 2026 May 05. Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-170X
DOI:10.1038/s41591-026-04437-z