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Probiotic-conditioned microbiota from preterm infants modulate immune response to pathogen challenge in a microbiota-humanized mouse model.

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Title: Probiotic-conditioned microbiota from preterm infants modulate immune response to pathogen challenge in a microbiota-humanized mouse model.
Authors: Smout J; Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany., Lesker TR; Department of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany., Hoenicke L; Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Ortiz D; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.; Department of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany., Zou M; Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Kruse F; Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Pirr S; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany., Willers M; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany., Härtel C; Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany., Falk C; Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany.; German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, Hannover, Germany., Torow N; Junior Research Group Early Life Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Viemann D; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.; Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany.; Center for Infection Research, University Würzburg, Würzburg, Germany., Strowig T; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.; Department of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.; Center for Individualized Infection Medicine (CiiM), a joint venture of Hannover Medical School and Helmholtz Centre for Infection Research, Hannover, Germany., Huehn J; Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.
Source: Frontiers in immunology [Front Immunol] 2026 Apr 20; Vol. 17, pp. 1761680. Date of Electronic Publication: 2026 Apr 20 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Probiotic-conditioned microbiota from preterm infants modulate immune response to pathogen challenge in a microbiota-humanized mouse model.
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  Data: <searchLink fieldCode="AU" term="%22Smout+J%22">Smout J</searchLink>; Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Lesker+TR%22">Lesker TR</searchLink>; Department of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Hoenicke+L%22">Hoenicke L</searchLink>; Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Ortiz+D%22">Ortiz D</searchLink>; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.; Department of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Zou+M%22">Zou M</searchLink>; Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Kruse+F%22">Kruse F</searchLink>; Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Pirr+S%22">Pirr S</searchLink>; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Willers+M%22">Willers M</searchLink>; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Härtel+C%22">Härtel C</searchLink>; Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Falk+C%22">Falk C</searchLink>; Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany.; German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Torow+N%22">Torow N</searchLink>; Junior Research Group Early Life Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Viemann+D%22">Viemann D</searchLink>; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.; Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany.; Center for Infection Research, University Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Strowig+T%22">Strowig T</searchLink>; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.; Department of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.; Center for Individualized Infection Medicine (CiiM), a joint venture of Hannover Medical School and Helmholtz Centre for Infection Research, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Huehn+J%22">Huehn J</searchLink>; Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.
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