Three-Dimensional Visualization and Proteomic Analysis of Human Cardiac Transthyretin Amyloidosis Tissue Reveals Microangiopathy and Capillary Occlusion.

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Title: Three-Dimensional Visualization and Proteomic Analysis of Human Cardiac Transthyretin Amyloidosis Tissue Reveals Microangiopathy and Capillary Occlusion.
Authors: Donnelly JP; Department of Chemistry Chi-Huey Wong Laboratories for Biomedical, Research, Scripps Research La Jolla CA., Schäfer JH; Department of Chemistry Chi-Huey Wong Laboratories for Biomedical, Research, Scripps Research La Jolla CA.; Department of Integrative Structural and Computational Biology Scripps Research La Jolla CA., Yoon L; Department of Chemistry Chi-Huey Wong Laboratories for Biomedical, Research, Scripps Research La Jolla CA., Massey LA; Department of Chemistry Chi-Huey Wong Laboratories for Biomedical, Research, Scripps Research La Jolla CA., Ash C; Department of Chemistry Chi-Huey Wong Laboratories for Biomedical, Research, Scripps Research La Jolla CA., Gao Z; Department of Chemistry Chi-Huey Wong Laboratories for Biomedical, Research, Scripps Research La Jolla CA., Nugroho K; Department of Chemistry Chi-Huey Wong Laboratories for Biomedical, Research, Scripps Research La Jolla CA., Jäger M; Department of Chemistry Chi-Huey Wong Laboratories for Biomedical, Research, Scripps Research La Jolla CA., Pang Z; Department of Neuroscience Dorris Neuroscience Center, Scripps Research La Jolla CA., O'Neill RT; Department of Chemistry Chi-Huey Wong Laboratories for Biomedical, Research, Scripps Research La Jolla CA., Maurer MS; Cardiac Amyloidosis Program, Centre for Advanced Cardiac Care Columbia University Irving Medical Centre, New York Presbyterian Hospital New York NY., Powers ET; Department of Chemistry Chi-Huey Wong Laboratories for Biomedical, Research, Scripps Research La Jolla CA., Lander GC; Department of Integrative Structural and Computational Biology Scripps Research La Jolla CA., Ye L; Department of Integrative Structural and Computational Biology Scripps Research La Jolla CA.; Howard Hughes Medical Institute Chevy Chase MD., Kelly JW; Department of Chemistry Chi-Huey Wong Laboratories for Biomedical, Research, Scripps Research La Jolla CA.
Source: Journal of the American Heart Association [J Am Heart Assoc] 2026 May 19; Vol. 15 (10), pp. e042248. Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2047-9980
DOI:10.1161/JAHA.125.042248