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VRC01 with antiretroviral initiation in infants is well tolerated, and higher concentrations associate with greater HIV-1 DNA declines.

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Title: VRC01 with antiretroviral initiation in infants is well tolerated, and higher concentrations associate with greater HIV-1 DNA declines.
Authors: Khaitan A; Indiana University School of Medicine, Indianapolis, IN 46202, USA., Lindsey JC; Center for Biostatistics in AIDS Research, Harvard TH Chan School of Public Health, Boston, MA 02115, USA., Capparelli EV; University of California, San Diego, San Diego, CA 92093, USA., Tierney C; Center for Biostatistics in AIDS Research, Harvard TH Chan School of Public Health, Boston, MA 02115, USA., Coletti A; IMPAACT Operations Center, FHI 360, Durham, NC 27701, USA., Perlowski C; IMPAACT Operations Center, FHI 360, Durham, NC 27701, USA., Yin DE; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA., Smith MEB; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA., Spiegel HML; Kelly Government Solutions, Contractor to National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA., Majji S; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Maternal and Pediatric Infectious Disease Branch, Bethesda, MD 20817, USA., Moye J; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Maternal and Pediatric Infectious Disease Branch, Bethesda, MD 20817, USA., Gama L; Vaccine Research Center, Bethesda, MD 20814, USA., Koup RA; Vaccine Research Center, Bethesda, MD 20814, USA., Lin BC; Vaccine Research Center, Bethesda, MD 20814, USA., McDermott AB; Vaccine Research Center, Bethesda, MD 20814, USA., Purdue L; Kelly Government Solutions, Contractor to National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA., Krotje C; Frontier Science Foundation, Amherst, NY 14226, USA., Harding PA; University of Colorado Anschutz School of Medicine, Denver, CO 80045, USA., Cotton MF; Family Centre for Research with Ubuntu (FAMCRU), Stellenbosch University, Stellenbosch 7505, South Africa., Costello D; MacDonald Research Laboratory, University of California at Los Angeles, Los Angeles, CA 90095, USA., Petropoulos CJ; Labcorp-Monogram Biosciences, South San Francisco, CA 94080, USA., Reeves JD; Labcorp-Monogram Biosciences, South San Francisco, CA 94080, USA., Mallewa M; Kamuzu University of Health Sciences-Johns Hopkins Research Project, Blantyre 312223, Malawi., Chihana R; Kamuzu University of Health Sciences-Johns Hopkins Research Project, Blantyre 312223, Malawi., Kamthunzi P; UNC Malawi CRS, Lilongwe 207233, Malawi., Mbengeranwa TG; Clinical Trials Research Centre, University of Zimbabwe, Harare Zimbabwe., Masheto G; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana., Santos Cruz ML; Hospital Federal dos Servidores do Estado, Rio de Janeiro, RJ 20221-903, Brazil., Pilotto JH; Hospital Geral de Nova Iguaçu & Laboratório de Aids e Imunologia Molecular/IOC, Nova Iguaçu, RJ 26030-380, Brazil., Ponatshego PL; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana., Persaud D; Johns Hopkins University, Baltimore, MD 21205, USA., McFarland EJ; University of Colorado Anschutz School of Medicine, Denver, CO 80045, USA.
Corporate Authors: IMPAACT 2008 Team
Source: Science translational medicine [Sci Transl Med] 2026 May 06; Vol. 18 (848), pp. eadr4509. Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: VRC01 with antiretroviral initiation in infants is well tolerated, and higher concentrations associate with greater HIV-1 DNA declines.
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  Data: <searchLink fieldCode="AU" term="%22Khaitan+A%22">Khaitan A</searchLink>; Indiana University School of Medicine, Indianapolis, IN 46202, USA.<br /><searchLink fieldCode="AU" term="%22Lindsey+JC%22">Lindsey JC</searchLink>; Center for Biostatistics in AIDS Research, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Capparelli+EV%22">Capparelli EV</searchLink>; University of California, San Diego, San Diego, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Tierney+C%22">Tierney C</searchLink>; Center for Biostatistics in AIDS Research, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Coletti+A%22">Coletti A</searchLink>; IMPAACT Operations Center, FHI 360, Durham, NC 27701, USA.<br /><searchLink fieldCode="AU" term="%22Perlowski+C%22">Perlowski C</searchLink>; IMPAACT Operations Center, FHI 360, Durham, NC 27701, USA.<br /><searchLink fieldCode="AU" term="%22Yin+DE%22">Yin DE</searchLink>; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA.<br /><searchLink fieldCode="AU" term="%22Smith+MEB%22">Smith MEB</searchLink>; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA.<br /><searchLink fieldCode="AU" term="%22Spiegel+HML%22">Spiegel HML</searchLink>; Kelly Government Solutions, Contractor to National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA.<br /><searchLink fieldCode="AU" term="%22Majji+S%22">Majji S</searchLink>; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Maternal and Pediatric Infectious Disease Branch, Bethesda, MD 20817, USA.<br /><searchLink fieldCode="AU" term="%22Moye+J%22">Moye J</searchLink>; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Maternal and Pediatric Infectious Disease Branch, Bethesda, MD 20817, USA.<br /><searchLink fieldCode="AU" term="%22Gama+L%22">Gama L</searchLink>; Vaccine Research Center, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Koup+RA%22">Koup RA</searchLink>; Vaccine Research Center, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Lin+BC%22">Lin BC</searchLink>; Vaccine Research Center, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22McDermott+AB%22">McDermott AB</searchLink>; Vaccine Research Center, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Purdue+L%22">Purdue L</searchLink>; Kelly Government Solutions, Contractor to National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA.<br /><searchLink fieldCode="AU" term="%22Krotje+C%22">Krotje C</searchLink>; Frontier Science Foundation, Amherst, NY 14226, USA.<br /><searchLink fieldCode="AU" term="%22Harding+PA%22">Harding PA</searchLink>; University of Colorado Anschutz School of Medicine, Denver, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Cotton+MF%22">Cotton MF</searchLink>; Family Centre for Research with Ubuntu (FAMCRU), Stellenbosch University, Stellenbosch 7505, South Africa.<br /><searchLink fieldCode="AU" term="%22Costello+D%22">Costello D</searchLink>; MacDonald Research Laboratory, University of California at Los Angeles, Los Angeles, CA 90095, USA.<br /><searchLink fieldCode="AU" term="%22Petropoulos+CJ%22">Petropoulos CJ</searchLink>; Labcorp-Monogram Biosciences, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Reeves+JD%22">Reeves JD</searchLink>; Labcorp-Monogram Biosciences, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Mallewa+M%22">Mallewa M</searchLink>; Kamuzu University of Health Sciences-Johns Hopkins Research Project, Blantyre 312223, Malawi.<br /><searchLink fieldCode="AU" term="%22Chihana+R%22">Chihana R</searchLink>; Kamuzu University of Health Sciences-Johns Hopkins Research Project, Blantyre 312223, Malawi.<br /><searchLink fieldCode="AU" term="%22Kamthunzi+P%22">Kamthunzi P</searchLink>; UNC Malawi CRS, Lilongwe 207233, Malawi.<br /><searchLink fieldCode="AU" term="%22Mbengeranwa+TG%22">Mbengeranwa TG</searchLink>; Clinical Trials Research Centre, University of Zimbabwe, Harare Zimbabwe.<br /><searchLink fieldCode="AU" term="%22Masheto+G%22">Masheto G</searchLink>; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Santos+Cruz+ML%22">Santos Cruz ML</searchLink>; Hospital Federal dos Servidores do Estado, Rio de Janeiro, RJ 20221-903, Brazil.<br /><searchLink fieldCode="AU" term="%22Pilotto+JH%22">Pilotto JH</searchLink>; Hospital Geral de Nova Iguaçu & Laboratório de Aids e Imunologia Molecular/IOC, Nova Iguaçu, RJ 26030-380, Brazil.<br /><searchLink fieldCode="AU" term="%22Ponatshego+PL%22">Ponatshego PL</searchLink>; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Persaud+D%22">Persaud D</searchLink>; Johns Hopkins University, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22McFarland+EJ%22">McFarland EJ</searchLink>; University of Colorado Anschutz School of Medicine, Denver, CO 80045, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2026 May 06; Vol. 18 (848), pp. eadr4509. <i>Date of Electronic Publication: </i>2026 May 06.
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