Antagonistic pleiotropy in disease tolerance: Foxo1-Trim63 axis as double-edged sword in age-dependent sepsis.

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Title: Antagonistic pleiotropy in disease tolerance: Foxo1-Trim63 axis as double-edged sword in age-dependent sepsis.
Authors: Chae U; Futuristic Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea. unebin@kribb.re.kr., Kim JM; Department of Pathology, Konyang University Medical Center, Daejeon, Republic of Korea. 200833@kyuh.ac.kr., Park YH; Futuristic Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea. pyh2877@kribb.re.kr.; Advanced Bioconvergence Department, KRIBB School, Korea National University of Science and Technology (UST), Daejeon, Republic of Korea. pyh2877@kribb.re.kr.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 May 07; Vol. 11 (1). Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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ISSN:2059-3635
DOI:10.1038/s41392-026-02739-9