MAPK/PMK-1 innate immune signaling protects the nematode Caenorhabditis elegans from increased intestinal colonization in an animal host-pathogen model in space.

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Title: MAPK/PMK-1 innate immune signaling protects the nematode Caenorhabditis elegans from increased intestinal colonization in an animal host-pathogen model in space.
Authors: Alcantara AV Jr; Division of Biological Science and Technology, College of Science and Technology, Yonsei University Mirae Campus, Wonju, South Korea., Indong RA; Division of Biological Science and Technology, College of Science and Technology, Yonsei University Mirae Campus, Wonju, South Korea., Yoon KH; Organelle Medicine Research Center, Yonsei University Wonju College of Medicine, Wonju, South Korea.; Department of Global Medical Science, Yonsei University Wonju College of Medicine, Wonju, South Korea., Kim BS; Division of Biological Science and Technology, College of Science and Technology, Yonsei University Mirae Campus, Wonju, South Korea., Hashizume T; Advanced Engineering Services, Tsukuba, Japan.; Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan., Higashibata A; Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan., Higashitani A; Department of Environmental Life Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan., Szewczyk NJ; Department of Biomedical Sciences, Ohio University, Athens, OH, USA., Etheridge T; Department of Physical Therapy, College of Health Sciences and Professions, Ohio University, Athens, OH, USA., Deane CS; Human Development & Health, Faculty of Medicine, Southampton General Hospital, University of Southampton, Southampton, UK., Ellwood RA; Medical Research Council (MRC) Versus Arthritis Centre for Musculoskeletal Ageing Research, Royal Derby Hospital, University of Nottingham, Derby, UK., Kim HS; Division of Biomedical Engineering, Yonsei University Mirae Campus, Wonju, South Korea., Mitchell RJ; Ulsan National Institute of Science and Technology, Ulsan, South Korea., Lee JI; Division of Biological Science and Technology, College of Science and Technology, Yonsei University Mirae Campus, Wonju, South Korea. jinillee@yonsei.ac.kr.; Organelle Medicine Research Center, Yonsei University Wonju College of Medicine, Wonju, South Korea. jinillee@yonsei.ac.kr.
Source: NPJ microgravity [NPJ Microgravity] 2026 May 06. Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: United States NLM ID: 101703605 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2373-8065 (Print) Linking ISSN: 23738065 NLM ISO Abbreviation: NPJ Microgravity
Database: MEDLINE Ultimate
Description
ISSN:2373-8065
DOI:10.1038/s41526-026-00603-2