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Disrupted molecular glue complex drives RAS inhibitor resistance.

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Title: Disrupted molecular glue complex drives RAS inhibitor resistance.
Authors: Sang B; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ye LF; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Fu Z; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Pourfarjam Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Cuevas-Navarro A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Fan S; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Hu F; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Washington A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Rodriguez DJ; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Tri-Institutional MD-PhD Program, Weill Cornell Medical College, Rockefeller University, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Vides A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kar S; Revolution Medicines, Redwood City, CA, USA., Ahler E; Revolution Medicines, Redwood City, CA, USA., Lin KK; Revolution Medicines, Redwood City, CA, USA., Hegde A; Revolution Medicines, Redwood City, CA, USA., Smith JAM; Revolution Medicines, Redwood City, CA, USA., Wolpin BM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Punekar SR; Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA., Spira AI; Virginia Cancer Specialists Research Institute, Fairfax, VA, USA., Garrido-Laguna I; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Hong DS; Department of Investigational Cancer Therapeutics, MD Anderson Cancer Center, Houston, TX, USA., Dar AC; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Yaeger R; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Arbour KC; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Lito P; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Tri-Institutional MD-PhD Program, Weill Cornell Medical College, Rockefeller University, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA. Electronic address: litop@mskcc.org.
Source: Cell [Cell] 2026 May 14; Vol. 189 (10), pp. 2918-2933.e17. Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
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  Data: Disrupted molecular glue complex drives RAS inhibitor resistance.
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  Data: <searchLink fieldCode="AU" term="%22Sang+B%22">Sang B</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ye+LF%22">Ye LF</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Fu+Z%22">Fu Z</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Pourfarjam+Y%22">Pourfarjam Y</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cuevas-Navarro+A%22">Cuevas-Navarro A</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Fan+S%22">Fan S</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hu+F%22">Hu F</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Washington+A%22">Washington A</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+DJ%22">Rodriguez DJ</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Tri-Institutional MD-PhD Program, Weill Cornell Medical College, Rockefeller University, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Vides+A%22">Vides A</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kar+S%22">Kar S</searchLink>; Revolution Medicines, Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ahler+E%22">Ahler E</searchLink>; Revolution Medicines, Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lin+KK%22">Lin KK</searchLink>; Revolution Medicines, Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hegde+A%22">Hegde A</searchLink>; Revolution Medicines, Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Smith+JAM%22">Smith JAM</searchLink>; Revolution Medicines, Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wolpin+BM%22">Wolpin BM</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Punekar+SR%22">Punekar SR</searchLink>; Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Spira+AI%22">Spira AI</searchLink>; Virginia Cancer Specialists Research Institute, Fairfax, VA, USA.<br /><searchLink fieldCode="AU" term="%22Garrido-Laguna+I%22">Garrido-Laguna I</searchLink>; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Hong+DS%22">Hong DS</searchLink>; Department of Investigational Cancer Therapeutics, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Dar+AC%22">Dar AC</searchLink>; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Yaeger+R%22">Yaeger R</searchLink>; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Arbour+KC%22">Arbour KC</searchLink>; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lito+P%22">Lito P</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Tri-Institutional MD-PhD Program, Weill Cornell Medical College, Rockefeller University, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA. Electronic address: litop@mskcc.org.
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  Data: <searchLink fieldCode="JN" term="%220413066%22">Cell</searchLink> [Cell] 2026 May 14; Vol. 189 (10), pp. 2918-2933.e17. <i>Date of Electronic Publication: </i>2026 May 05.
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