Structural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder.

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Title: Structural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder.
Authors: Nabulsi L; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, University of Southern California, Marina del Rey, California; Clinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition and Genomics, Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland. Electronic address: lnabulsi@usc.edu., Kang MJY; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, University of Southern California, Marina del Rey, California., Jahanshad N; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, University of Southern California, Marina del Rey, California., McPhilemy G; Clinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition and Genomics, Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland., Martyn FM; Clinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition and Genomics, Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland., Haarman B; Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., McDonald C; Clinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition and Genomics, Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland., Hallahan B; Clinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition and Genomics, Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland., O'Donoghue S; Clinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition and Genomics, Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland., Stein DJ; Neuroscience Institute, University of Cape Town, Cape Town, South Africa; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; South African Medical Research Council Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa., Howells FM; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa., Scheffler F; Neuroscience Institute, University of Cape Town, Cape Town, South Africa; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa., Temmingh HS; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa., Glahn DC; Department of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Rodrigue A; Department of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Pomarol-Clotet E; Biomedical Research Networking Center for Mental Health Network, Instituto de Salud Carlos III, Madrid, Spain; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain., Vieta E; Biomedical Research Networking Center for Mental Health Network, Instituto de Salud Carlos III, Madrid, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain; Barcelona Bipolar Disorders and Depressive Unit, Hospital Clínic, Institute of Neurosciences, University of Barcelona, Barcelona, Spain., Radua J; Biomedical Research Networking Center for Mental Health Network, Instituto de Salud Carlos III, Madrid, Spain; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain; Barcelona Bipolar Disorders and Depressive Unit, Hospital Clínic, Institute of Neurosciences, University of Barcelona, Barcelona, Spain., Salvador R; Biomedical Research Networking Center for Mental Health Network, Instituto de Salud Carlos III, Madrid, Spain; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain., Karuk A; Biomedical Research Networking Center for Mental Health Network, Instituto de Salud Carlos III, Madrid, Spain; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain., Canales-Rodríguez EJ; Biomedical Research Networking Center for Mental Health Network, Instituto de Salud Carlos III, Madrid, Spain; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Signal Processing Laboratory, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Houenou J; Northern Health, Mental Health Division, and the University of Melbourne, Melbourne, Victoria, Australia., Favre P; Institut National de la Santé et de la Recherche Médicale U955, team 'Translational Neuro-Psychiatry,' Créteil, France; Neurospin, CEA Paris-Saclay, team 'Translational and Applicative Neuroimaging Research Unit,' Gif-sur-Yvette, France., Polosan M; University Grenoble Alpes, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France; Institut National de la Santé et de la Recherche Médicale U1216, Grenoble Institut des Neurosciences, La Tronche, France., Pouchon A; University Grenoble Alpes, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France; Institut National de la Santé et de la Recherche Médicale U1216, Grenoble Institut des Neurosciences, La Tronche, France., Brambilla P; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Department of Neurosciences and Mental Health, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Bellani M; Section of Psychiatry, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy., Mitchell PB; Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia., Roberts G; Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, Germany; Department of Psychiatry, Protestant Hospital of the Bethel Foundation, Medical School and University Medical Center OWL, Bielefeld University, Bielefeld, Germany., Borgers T; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Meinert S; Institute for Translational Psychiatry, University of Münster, Münster, Germany; Institute for Translational Neuroscience, University of Münster, Münster, Germany., Flinkenflügel K; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Repple J; Institute for Translational Psychiatry, University of Münster, Münster, Germany; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, University Hospital, Frankfurt, Germany; Cooperative Brain Imaging Center, Goethe University Frankfurt, Frankfurt, Germany., Leehr EJ; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Grotegerd D; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Hahn T; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Wessa M; Central Institute of Mental Health, Department of Neuropsychology and Psychological Resilience Research, Mannheim, Germany; DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany; Department of Cancer Survivorship and Psychological Resilience, German Cancer Research Center Heidelberg, Heidelberg, Germany., Phillips ML; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania., Teutenberg L; Department of Psychiatry and Psychotherapy, Faculty of Medicine, Philipps-Universität Marburg, Marburg, Germany., Kircher T; Department of Psychiatry and Psychotherapy, Faculty of Medicine, Philipps-Universität Marburg, Marburg, Germany., Straube B; Department of Psychiatry and Psychotherapy, Faculty of Medicine, Philipps-Universität Marburg, Marburg, Germany., Steinstraeter O; Department of Psychiatry and Psychotherapy, Faculty of Medicine, Philipps-Universität Marburg, Marburg, Germany., Stein F; Department of Psychiatry and Psychotherapy, Faculty of Medicine, Philipps-Universität Marburg, Marburg, Germany., Thomas-Odenthal F; Department of Psychiatry and Psychotherapy, Faculty of Medicine, Philipps-Universität Marburg, Marburg, Germany., Alexander N; Department of Psychiatry and Psychotherapy, Faculty of Medicine, Philipps-Universität Marburg, Marburg, Germany., Usemann PL; Department of Psychiatry and Psychotherapy, Faculty of Medicine, Philipps-Universität Marburg, Marburg, Germany., Jansen A; Department of Psychiatry and Psychotherapy, Faculty of Medicine, Philipps-Universität Marburg, Marburg, Germany; Core-Facility Brainimaging, Faculty of Medicine, University of Marburg, Marburg, Germany., Berk M; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia; IMPACT Institute, School of Medicine, Deakin University, Geelong, Victoria, Australia; Orygen Youth Health Clinical Program, Parkville, Victoria, Australia; Barwon Health and the Geelong Clinic, Geelong, Victoria, Australia., Dandash O; Brain and Mental Health Laboratory, School of Psychological Science and Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, Victoria, Australia; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia., Parker N; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Suo C; Turner Institute for Brain and Mental Health, School of Psychological Science and Monash Biomedical Imaging, Monash University, Victoria, Australia; Queensland Institute of Medical Research Berghofer, Berghofer, Queensland, Australia; Healthy Brain and Mind Research Centre, School of Behavioral and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Fitzroy, Victoria, Australia; School of Psychology, University of Queensland, Brisbane, Queensland, Australia., Thomopoulos SI; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, University of Southern California, Marina del Rey, California., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, University of Southern California, Marina del Rey, California., Andreassen OA; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Ching CRK; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, University of Southern California, Marina del Rey, California., Cannon DM; Clinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition and Genomics, Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.
Corporate Authors: ENIGMA Bipolar Disorder Working Group
Source: Biological psychiatry [Biol Psychiatry] 2026 May 04. Date of Electronic Publication: 2026 May 04.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0213264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2402 (Electronic) Linking ISSN: 00063223 NLM ISO Abbreviation: Biol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-2402
DOI:10.1016/j.biopsych.2026.04.020