Single-cell transcriptomics reveal altered B cell responses and T cell senescence in geriatric non-responders to COVID-19 mRNA vaccination.

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Bibliographic Details
Title: Single-cell transcriptomics reveal altered B cell responses and T cell senescence in geriatric non-responders to COVID-19 mRNA vaccination.
Authors: Ismail J; Systems Biology and Bioinformatics Program, Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Tamilselvan B; Systems Biology and Bioinformatics Program, Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Rubsamen M; Systems Biology and Bioinformatics Program, Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Petrosky J; Systems Biology and Bioinformatics Program, Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Richardson B; Systems Biology and Bioinformatics Program, Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Zagore L; Systems Biology and Bioinformatics Program, Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Oyebanji OA; Case Western Reserve University School of Medicine, Cleveland, OH, USA., Keresztesy D; Case Western Reserve University School of Medicine, Cleveland, OH, USA., Payne M; Case Western Reserve University School of Medicine, Cleveland, OH, USA., Wilk D; Case Western Reserve University School of Medicine, Cleveland, OH, USA., Carias L; Case Western Reserve University School of Medicine, Cleveland, OH, USA., Aung H; Case Western Reserve University School of Medicine, Cleveland, OH, USA., St Denis K; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Sheehan M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Wilson BM; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA., Balazs AB; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Gravenstein S; Warren Alpert Medical School, Brown University, Providence, RI, USA.; Department of Health Services, Policy and Practice, School of Public Health, Brown University, Providence, RI, USA.; Center of Innovation in Long-Term Services and Supports, Veterans Administration (VA) Medical Center, Providence, RI, USA., King CL; Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA., Canaday DH; Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA., Cameron CM; Systems Biology and Bioinformatics Program, Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Cameron MJ; Systems Biology and Bioinformatics Program, Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Source: IScience [iScience] 2026 Apr 16; Vol. 29 (5), pp. 115730. Date of Electronic Publication: 2026 Apr 16 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2589-0042
DOI:10.1016/j.isci.2026.115730