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How PPMI Enabled the First Interventional Platform Trial to Test Therapies in Participants With Early-Stage Neuronal Alpha-Synuclein Disease.

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Title: How PPMI Enabled the First Interventional Platform Trial to Test Therapies in Participants With Early-Stage Neuronal Alpha-Synuclein Disease.
Authors: Simuni T; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL., Coffey CS; Department of Biostatistics, University of Iowa, Iowa City, IA., Kopil CM; The Michael J. Fox Foundation for Parkinson's Research, New York, NY., Allen-Savietta C; Berry Consultants, LLC, Austin, TX., Wendelberger B; Berry Consultants, LLC, Austin, TX., Crawford A; Berry Consultants, LLC, Austin, TX., Schneider RB; Department of Neurology, University of Rochester, Rochester, NY., Siderowf A; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Kieburtz K; Department of Neurology, University of Rochester, Rochester, NY., Tanner CM; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA., Tropea TF; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Institute for Neurodegenerative Disorders, New Haven, CT., Whalen H; Institute for Neurodegenerative Disorders, New Haven, CT., Ramia L; Institute for Neurodegenerative Disorders, New Haven, CT., Kamp C; Department of Neurology, University of Rochester, Rochester, NY., Reyes C; Institute for Neurodegenerative Disorders, New Haven, CT., Fabrizio K; Institute for Neurodegenerative Disorders, New Haven, CT., Willson T; The Michael J. Fox Foundation for Parkinson's Research, New York, NY., Merriam E; Institute for Neurodegenerative Disorders, New Haven, CT., Kuhl MM; The Michael J. Fox Foundation for Parkinson's Research, New York, NY., Chowdhury S; The Michael J. Fox Foundation for Parkinson's Research, New York, NY., Marek K; Institute for Neurodegenerative Disorders, New Haven, CT.
Corporate Authors: Parkinson's Progression Markers Initiative
Source: Annals of neurology [Ann Neurol] 2026 May 07. Date of Electronic Publication: 2026 May 07.
Publication Type: Editorial
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7707449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8249 (Electronic) Linking ISSN: 03645134 NLM ISO Abbreviation: Ann Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: How PPMI Enabled the First Interventional Platform Trial to Test Therapies in Participants With Early-Stage Neuronal Alpha-Synuclein Disease.
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  Data: <searchLink fieldCode="AU" term="%22Simuni+T%22">Simuni T</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL.<br /><searchLink fieldCode="AU" term="%22Coffey+CS%22">Coffey CS</searchLink>; Department of Biostatistics, University of Iowa, Iowa City, IA.<br /><searchLink fieldCode="AU" term="%22Kopil+CM%22">Kopil CM</searchLink>; The Michael J. Fox Foundation for Parkinson's Research, New York, NY.<br /><searchLink fieldCode="AU" term="%22Allen-Savietta+C%22">Allen-Savietta C</searchLink>; Berry Consultants, LLC, Austin, TX.<br /><searchLink fieldCode="AU" term="%22Wendelberger+B%22">Wendelberger B</searchLink>; Berry Consultants, LLC, Austin, TX.<br /><searchLink fieldCode="AU" term="%22Crawford+A%22">Crawford A</searchLink>; Berry Consultants, LLC, Austin, TX.<br /><searchLink fieldCode="AU" term="%22Schneider+RB%22">Schneider RB</searchLink>; Department of Neurology, University of Rochester, Rochester, NY.<br /><searchLink fieldCode="AU" term="%22Siderowf+A%22">Siderowf A</searchLink>; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Kieburtz+K%22">Kieburtz K</searchLink>; Department of Neurology, University of Rochester, Rochester, NY.<br /><searchLink fieldCode="AU" term="%22Tanner+CM%22">Tanner CM</searchLink>; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Tropea+TF%22">Tropea TF</searchLink>; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Institute for Neurodegenerative Disorders, New Haven, CT.<br /><searchLink fieldCode="AU" term="%22Whalen+H%22">Whalen H</searchLink>; Institute for Neurodegenerative Disorders, New Haven, CT.<br /><searchLink fieldCode="AU" term="%22Ramia+L%22">Ramia L</searchLink>; Institute for Neurodegenerative Disorders, New Haven, CT.<br /><searchLink fieldCode="AU" term="%22Kamp+C%22">Kamp C</searchLink>; Department of Neurology, University of Rochester, Rochester, NY.<br /><searchLink fieldCode="AU" term="%22Reyes+C%22">Reyes C</searchLink>; Institute for Neurodegenerative Disorders, New Haven, CT.<br /><searchLink fieldCode="AU" term="%22Fabrizio+K%22">Fabrizio K</searchLink>; Institute for Neurodegenerative Disorders, New Haven, CT.<br /><searchLink fieldCode="AU" term="%22Willson+T%22">Willson T</searchLink>; The Michael J. Fox Foundation for Parkinson's Research, New York, NY.<br /><searchLink fieldCode="AU" term="%22Merriam+E%22">Merriam E</searchLink>; Institute for Neurodegenerative Disorders, New Haven, CT.<br /><searchLink fieldCode="AU" term="%22Kuhl+MM%22">Kuhl MM</searchLink>; The Michael J. Fox Foundation for Parkinson's Research, New York, NY.<br /><searchLink fieldCode="AU" term="%22Chowdhury+S%22">Chowdhury S</searchLink>; The Michael J. Fox Foundation for Parkinson's Research, New York, NY.<br /><searchLink fieldCode="AU" term="%22Marek+K%22">Marek K</searchLink>; Institute for Neurodegenerative Disorders, New Haven, CT.
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