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Biocatalytic cascades enable manufacture of the macrocyclic peptide enlicitide.

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Title: Biocatalytic cascades enable manufacture of the macrocyclic peptide enlicitide.
Authors: Klapars A; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Fryszkowska A; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Galanie S; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Ad O; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Aguilera EY; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Akporji N; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., An C; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Axnanda S; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Ayele TM; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Ayikpoe RS; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Barrientos RC; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Bauerle MR; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Becker MR; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Belyk KM; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Bereznitski L; Global Science, Engineering, and Commercialization, Merck & Co., Inc., Rahway, NJ, USA., Cahn JKB; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Soto KC; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Campeau LC; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Campos KR; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Chandra A; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Chang HYD; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Chen M; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Chen Z; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Cheung-Lee WL; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Chung CK; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Chun SW; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Co SS; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Cohen RD; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Dalby SM; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Dal Poggetto G; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Do T; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Dreher SD; Discovery, Preclinical, and Translational Medicine, Merck & Co., Inc., Rahway, NJ, USA., Drout RJ; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Dunham NP; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Fan Y; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Flessner RM; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Forstater JH; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., France SP; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Gamekkanda JC; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Gauthier DR Jr; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Gil AA; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Greenwood JW; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Ha N; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Halsey HM; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Han X; Global Science, Engineering, and Commercialization, Merck & Co., Inc., Rahway, NJ, USA., Hartmann M; Discovery, Preclinical, and Translational Medicine, Merck & Co., Inc., Rahway, NJ, USA., Hartmanshenn C; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., He Y; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Hernandez E; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Hiraga K; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Ho HI; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Hong CM; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Hruza A; Discovery, Preclinical, and Translational Medicine, Merck & Co., Inc., Rahway, NJ, USA., Hu H; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Hullen K; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Hyde AM; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Itoh T; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Jones CM; Discovery, Preclinical, and Translational Medicine, Merck & Co., Inc., Rahway, NJ, USA., Jung WO; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Kanuga K; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Knippel JL; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Kolev JN; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Kong J; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Kosjek B; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Koynov S; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Kress MH; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA.; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Krishnamurthi B; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Kuethe JT; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Kwok TT; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Lee AY; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Lee J; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Li Q; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Li S; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Liao J; Global Science, Engineering, and Commercialization, Merck & Co., Inc., Rahway, NJ, USA., Liu W; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Longia G; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Madrigal E; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Maligres PE; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Maloney KM; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., McCarthy EL; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., McIntosh JA; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Mesbahi-Vasey S; Discovery, Preclinical, and Translational Medicine, Merck & Co., Inc., Rahway, NJ, USA., Miller M; Global Science, Engineering, and Commercialization, Merck & Co., Inc., Rahway, NJ, USA., Modi M; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Moore JC; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Mukherjee D; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Murphy GS; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Obligacion JV; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Pan W; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Parzecki J; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Patel A; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Peng T; Global Science, Engineering, and Commercialization, Merck & Co., Inc., Rahway, NJ, USA., Peters BK; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Piou T; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Pons Siepermann CA; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Prier CK; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Purohit AK; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Qin Y; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Regalado EL; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Reibarkh M; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Rivera NR; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Robaire SA; Global Science, Engineering, and Commercialization, Merck & Co., Inc., Rahway, NJ, USA., Robison L; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Row RD; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Roy S; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Ruck RT; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Rykaczewski KA; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Schuster CH; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Schwalm EL; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Singh AN; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Sirota E; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Sun AC; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Tang W; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Thaisrivongs DA; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Thakur N; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Tong W; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Truong V; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Tsoi R; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Tu Q; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Turnbull BWH; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Ukaegbu O; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Vargas DA; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Velasquez JE; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Verma D; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Wang H; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Wang T; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Wang X; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Wang Y; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Wang Z; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Winston MS; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Wu C; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Wyvratt BM; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Xiao KJ; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Xu Y; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Yan JX; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Yang H; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Zhang V; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Zhang Y; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Zheng M; Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Zhong W; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA.
Source: Science (New York, N.Y.) [Science] 2026 May 07; Vol. 392 (6798), pp. 643-647. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1095-9203
DOI:10.1126/science.aed8713