SLX4IP limits replication stress globally and at ALT telomeres.
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| Title: | SLX4IP limits replication stress globally and at ALT telomeres. |
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| Authors: | Spindler J; Max Planck Institute for Biology of Ageing, Cologne, Germany., Pandolfo F; Max Planck Institute for Biology of Ageing, Cologne, Germany., Koch AE; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Piccirillo P; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Jordahl D; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; National Center for Quantitative Biology of Complex Systems, University of Wisconsin-Madison, Madison, WI, USA., Venkatesh N; Max Planck Institute for Biology of Ageing, Cologne, Germany., Suresh D; Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA., Ylvisaker KR; Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA., Jopkiewicz A; Max Planck Institute for Biology of Ageing, Cologne, Germany., Bihler J; Max Planck Institute for Biology of Ageing, Cologne, Germany., Buschbaum S; Max Planck Institute for Biology of Ageing, Cologne, Germany., Morgenstern M; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; National Center for Quantitative Biology of Complex Systems, University of Wisconsin-Madison, Madison, WI, USA., Overmyer KA; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; National Center for Quantitative Biology of Complex Systems, University of Wisconsin-Madison, Madison, WI, USA.; Morgridge Institute for Research, Madison, WI, USA., Vincendeau E; Max Planck Institute for Biology of Ageing, Cologne, Germany., Coon JJ; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; National Center for Quantitative Biology of Complex Systems, University of Wisconsin-Madison, Madison, WI, USA.; Morgridge Institute for Research, Madison, WI, USA.; Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA., Wei PC; Brain Mosaicism and Tumorigenesis, German Cancer Research Center, Heidelberg, Germany.; Interdisciplinary Center for Neuroscience, Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Hänsel-Hertsch R; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine, University of Cologne, Cologne, Germany.; Institute of Human Genetics, University Hospital Cologne, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne Excellence Cluster for Aging and Aging-Associated Diseases (CECAD), Cologne, Germany., Mehta KPM; Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA. kmehta@wisc.edu., Panier S; Max Planck Institute for Biology of Ageing, Cologne, Germany. panier@age.mpg.de.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne Excellence Cluster for Aging and Aging-Associated Diseases (CECAD), Cologne, Germany. panier@age.mpg.de.; Institute for Genome Stability in Aging and Disease, Medical Faculty, University of Cologne, Cologne, Germany. panier@age.mpg.de. |
| Source: | The EMBO journal [EMBO J] 2026 Jun; Vol. 45 (12), pp. 4176-4219. Date of Electronic Publication: 2026 May 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1460-2075 |
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| DOI: | 10.1038/s44318-026-00790-4 |
