Existential distress in advanced cancer: study protocol of a pragmatic randomized controlled trial of a short-term psychodynamic therapy (ORPHYS) compared to usual psycho-oncological treatment (TAU).

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Title: Existential distress in advanced cancer: study protocol of a pragmatic randomized controlled trial of a short-term psychodynamic therapy (ORPHYS) compared to usual psycho-oncological treatment (TAU).
Authors: Philipp R; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany. r.philipp@uke.de., Walbaum C; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany.; Department of Oncology, Hematology, and Bone Marrow Transplantation with section of Pneumology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-O24, Hamburg, Germany., Bokemeyer C; Department of Oncology, Hematology, and Bone Marrow Transplantation with section of Pneumology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-O24, Hamburg, Germany., Dinger U; Clinical Institute of Psychosomatic Medicine and Psychotherapy, Medical Faculty & University Hospital Düsseldorf, Heinrich-Heine University, Moorenstr. 5, Düsseldorf, Germany., Härter M; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany., Hemsen B; Clinical Institute of Psychosomatic Medicine and Psychotherapy, Medical Faculty & University Hospital Düsseldorf, Heinrich-Heine University, Moorenstr. 5, Düsseldorf, Germany., Holsteg S; Clinical Institute of Psychosomatic Medicine and Psychotherapy, Medical Faculty & University Hospital Düsseldorf, Heinrich-Heine University, Moorenstr. 5, Düsseldorf, Germany., Karger A; Clinical Institute of Psychosomatic Medicine and Psychotherapy, Medical Faculty & University Hospital Düsseldorf, Heinrich-Heine University, Moorenstr. 5, Düsseldorf, Germany., Koch U; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany., Kriston L; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany., Lezius S; Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-CPW 1, Hamburg, Germany., Lindner R; Institute of Social Work, University of Kassel, Arnold-Bode-Strasse 10, Kassel, Germany., Maatouk I; Department of Internal Medicine II, Chair of Integrated Psychosomatic Medicine and Psychotherapy, University Hospital Würzburg, Oberdürrbacher Str. 6, Würzburg, Germany., Oechsle K; Department of Oncology, Hematology, and Bone Marrow Transplantation with section of Pneumology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-O24, Hamburg, Germany., Scholl I; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany., Wagner A; Department of Internal Medicine II, Chair of Integrated Psychosomatic Medicine and Psychotherapy, University Hospital Würzburg, Oberdürrbacher Str. 6, Würzburg, Germany., Vehling S; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany.; Department of Oncology, Hematology, and Bone Marrow Transplantation with section of Pneumology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-O24, Hamburg, Germany.
Source: Trials [Trials] 2026 May 07; Vol. 27 (1). Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1745-6215
DOI:10.1186/s13063-026-09744-x