Noncanonical IRF3 function mediates STING-dependent pro-inflammatory cytokine production in macrophages.
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| Title: | Noncanonical IRF3 function mediates STING-dependent pro-inflammatory cytokine production in macrophages. |
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| Authors: | Balka KR; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.; Department of Systems Immunology and Proteomics, Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Lamb OR; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Venkatraman R; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Magill Z; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Hoang LT; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Dumbrill R; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., McArthur K; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., de Weerd NA; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia., Hertzog PJ; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia., Crack PJ; Department of Biochemistry and Pharmacology, The University of Melbourne, Parkville, VIC, Australia., Wakim LM; Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia., Good-Jacobson KL; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Lahoud MH; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., O'Keeffe M; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., De Nardo D; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia. dominic.denardo@monash.edu. |
| Source: | EMBO reports [EMBO Rep] 2026 Jun; Vol. 27 (11), pp. 2865-2892. Date of Electronic Publication: 2026 May 08. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1469-3178 |
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| DOI: | 10.1038/s44319-026-00793-6 |
