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Noncanonical IRF3 function mediates STING-dependent pro-inflammatory cytokine production in macrophages.

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Title: Noncanonical IRF3 function mediates STING-dependent pro-inflammatory cytokine production in macrophages.
Authors: Balka KR; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.; Department of Systems Immunology and Proteomics, Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Lamb OR; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Venkatraman R; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Magill Z; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Hoang LT; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Dumbrill R; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., McArthur K; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., de Weerd NA; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia., Hertzog PJ; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia., Crack PJ; Department of Biochemistry and Pharmacology, The University of Melbourne, Parkville, VIC, Australia., Wakim LM; Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia., Good-Jacobson KL; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Lahoud MH; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., O'Keeffe M; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., De Nardo D; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia. dominic.denardo@monash.edu.
Source: EMBO reports [EMBO Rep] 2026 Jun; Vol. 27 (11), pp. 2865-2892. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Noncanonical IRF3 function mediates STING-dependent pro-inflammatory cytokine production in macrophages.
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  Data: <searchLink fieldCode="AU" term="%22Balka+KR%22">Balka KR</searchLink>; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.; Department of Systems Immunology and Proteomics, Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Lamb+OR%22">Lamb OR</searchLink>; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Venkatraman+R%22">Venkatraman R</searchLink>; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Magill+Z%22">Magill Z</searchLink>; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hoang+LT%22">Hoang LT</searchLink>; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Dumbrill+R%22">Dumbrill R</searchLink>; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22McArthur+K%22">McArthur K</searchLink>; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22de+Weerd+NA%22">de Weerd NA</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hertzog+PJ%22">Hertzog PJ</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Crack+PJ%22">Crack PJ</searchLink>; Department of Biochemistry and Pharmacology, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Wakim+LM%22">Wakim LM</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Good-Jacobson+KL%22">Good-Jacobson KL</searchLink>; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Lahoud+MH%22">Lahoud MH</searchLink>; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22O'Keeffe+M%22">O'Keeffe M</searchLink>; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22De+Nardo+D%22">De Nardo D</searchLink>; Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia. dominic.denardo@monash.edu.
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  Data: <searchLink fieldCode="JN" term="%22100963049%22">EMBO reports</searchLink> [EMBO Rep] 2026 Jun; Vol. 27 (11), pp. 2865-2892. <i>Date of Electronic Publication: </i>2026 May 08.
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