Impact of introducing RTS,S/AS01E malaria vaccine on mortality in young children in Ghana, Kenya, and Malawi: an observational evaluation of a cluster-randomised implementation programme.

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Title: Impact of introducing RTS,S/AS01E malaria vaccine on mortality in young children in Ghana, Kenya, and Malawi: an observational evaluation of a cluster-randomised implementation programme.
Authors: Mwapasa V; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi., Asante KP; Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana; London School of Hygiene & Tropical Medicine, London, UK. Electronic address: kwakupoku.asante@kintampo-hrc.org., Milligan P; London School of Hygiene & Tropical Medicine, London, UK. Electronic address: paul.milligan@lshtm.ac.uk., Akech S; Kenya Medical Research Institute-Wellcome Trust Research Programme, Nairobi, Kenya; Global Health Center, Centers for Disease Control and Prevention, Kisumu, Kenya., Oduro A; Navrongo Health Research Centre, Research and Development Division, Ghana Health Service, Ghana., Mathanga DP; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi; Malaria Alert Centre, Kamuzu University of Health Sciences, Blantyre, Malawi., Fogelson A; London School of Hygiene & Tropical Medicine, London, UK., Kwambai TK; Malaria Branch, Division of Parasitic Diseases and Malaria, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Kisumu, Kenya., Hamel MJ; Department of Immunizations, Vaccines, and Biologicals, WHO, Geneva, Switzerland., Kapito-Tembo A; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi., Gyan T; Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana., Westercamp N; Malaria Branch, Division of Parasitic Diseases and Malaria, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA., Okine RNA; Global Malaria Programme, WHO, Geneva, Switzerland., Moore KA; London School of Hygiene & Tropical Medicine, London, UK; Murdoch Children's Research Institute, Infection and Immunity, New Vaccines, VIC, Australia., Pellaux-Furrer E; Department of Immunizations, Vaccines, and Biologicals, WHO, Geneva, Switzerland., Stanley CC; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi; Malaria Alert Centre, Kamuzu University of Health Sciences, Blantyre, Malawi., Ansong D; Agogo Malaria Research Centre, Agogo, Ghana; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Kariuki S; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Njuguna P; Global Malaria Programme, WHO, Geneva, Switzerland; PATH Center for Vaccine Innovation and Access, Nairobi, Kenya., Mvalo T; University of North Carolina Project-Malawi, Lilongwe, Malawi., Welaga P; C K Tedam University of Technology and Applied Sciences, Navrongo, Ghana., Otieno L; Kenya Medical Research Institute-United States Army Medical Research Directorate-Africa, Kisumu, Kenya., Snell P; London School of Hygiene & Tropical Medicine, London, UK., Schellenberg D; Global Malaria Programme, WHO, Geneva, Switzerland., Chimala A; Malaria Alert Centre, Kamuzu University of Health Sciences, Blantyre, Malawi., Afari EA; School of Public Health, University of Ghana, Accra, Ghana., Bejon P; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Maleta K; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi., Agbenyega T; Agogo Malaria Research Centre, Agogo, Ghana; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Snow RW; Kenya Medical Research Institute-Wellcome Trust Research Programme, Nairobi, Kenya; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Zulu M; University of North Carolina Project-Malawi, Lilongwe, Malawi., Odei-Lartey E; Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana., Chinkhumba J; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi; Malaria Alert Centre, Kamuzu University of Health Sciences, Blantyre, Malawi., Samuels AM; Malaria Branch, Division of Parasitic Diseases and Malaria, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Kisumu, Kenya; Malaria Branch, Division of Parasitic Diseases and Malaria, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Corporate Authors: Malaria Vaccine Programme Evaluation partners
Source: Lancet (London, England) [Lancet] 2026 May 09; Vol. 407 (10541), pp. 1796-1808.
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1474-547X
DOI:10.1016/S0140-6736(26)00248-5