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Influence of obesity on susceptibility to systemic symptoms and host responses to orthoflaviviral infection: a prospective observational study using yellow fever vaccine to simulate acute infection.

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Title: Influence of obesity on susceptibility to systemic symptoms and host responses to orthoflaviviral infection: a prospective observational study using yellow fever vaccine to simulate acute infection.
Authors: Syenina A; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, College Road, 169857, Singapore; Viral Research and Experimental Medicine Centre (ViREMiCS), SingHealth Duke-NUS Academic Medical Centre, 169856, Singapore., Tham CYL; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, College Road, 169857, Singapore; Viral Research and Experimental Medicine Centre (ViREMiCS), SingHealth Duke-NUS Academic Medical Centre, 169856, Singapore., Tng DJH; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, College Road, 169857, Singapore; Department of Infectious Diseases, Singapore General Hospital, Outram Road, 169608, Singapore., Chew VSY; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, College Road, 169857, Singapore; Viral Research and Experimental Medicine Centre (ViREMiCS), SingHealth Duke-NUS Academic Medical Centre, 169856, Singapore., Yee JX; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, College Road, 169857, Singapore; Viral Research and Experimental Medicine Centre (ViREMiCS), SingHealth Duke-NUS Academic Medical Centre, 169856, Singapore., Leong YS; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, College Road, 169857, Singapore; Viral Research and Experimental Medicine Centre (ViREMiCS), SingHealth Duke-NUS Academic Medical Centre, 169856, Singapore., Hamis NZ; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, College Road, 169857, Singapore; Viral Research and Experimental Medicine Centre (ViREMiCS), SingHealth Duke-NUS Academic Medical Centre, 169856, Singapore., Tan HC; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, College Road, 169857, Singapore., Joon HY; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, College Road, 169857, Singapore., Chan JT; Clinical Trials and Research Centre, Singapore General Hospital, Outram Road, 169608, Singapore., Yang Y; Clinical Trials and Research Centre, Singapore General Hospital, Outram Road, 169608, Singapore., Cheung YB; Centre for Quantitative Medicine, Duke-NUS Medical School, College Road, 169857, Singapore., Ong EZ; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, College Road, 169857, Singapore; Viral Research and Experimental Medicine Centre (ViREMiCS), SingHealth Duke-NUS Academic Medical Centre, 169856, Singapore., Low JG; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, College Road, 169857, Singapore; Viral Research and Experimental Medicine Centre (ViREMiCS), SingHealth Duke-NUS Academic Medical Centre, 169856, Singapore; Department of Infectious Diseases, Singapore General Hospital, Outram Road, 169608, Singapore. Electronic address: jenny.low@singhealth.com.sg., Ooi EE; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, College Road, 169857, Singapore; Viral Research and Experimental Medicine Centre (ViREMiCS), SingHealth Duke-NUS Academic Medical Centre, 169856, Singapore; Department of Translational Clinical Research, Singapore General Hospital, Outram Road, 169608, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, 117549, Singapore. Electronic address: engeong.ooi@duke-nus.edu.sg.
Source: EBioMedicine [EBioMedicine] 2026 Jun; Vol. 128, pp. 106290. Date of Electronic Publication: 2026 May 09.
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2352-3964
DOI:10.1016/j.ebiom.2026.106290