iS2C2: a cointelligent platform for mechanistic discovery of disease cellular crosstalk.
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| Title: | iS2C2: a cointelligent platform for mechanistic discovery of disease cellular crosstalk. |
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| Authors: | Sheng J; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA. jsheng@houstonmethodist.org.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA. jsheng@houstonmethodist.org., Ahn JY; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Texas A&M University College of Medicine, Bryan, TX, USA.; Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA., Yang L; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA. lyang@houstonmethodist.org.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA. lyang@houstonmethodist.org., Wan Z; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA., Qi S; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA., Yu X; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA., Xu Z; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Cao Y; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA., Vasquez M; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA., Irfan A; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA., Zhu Y; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Department of Bioengineering, Rice University, Houston, TX, USA., Zhao H; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA., Yin Z; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA., Zhu Y; Department of Genomic Medicine, University of Texas M.D. Anderson Cancer Center, Austin, TX, USA., Ding Y; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Faridar A; Departments of Radiology, Medicine, and Urology, Houston Methodist Hospital, Houston, TX, USA., Wang L; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA., Liu F; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Wang H; Department of Laboratory Medicine, University of Texas M.D. Anderson Cancer Center, Austin, TX, USA., Ji Z; Med-Surg units, Ben Taub Hospital, Austin, TX, USA., Mao D; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Chan M; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA., Kermany D; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Texas A&M University College of Medicine, Bryan, TX, USA.; Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA., Dong W; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA., Kim DY; Genetics and Aging Research Unit, Department of Neurology, Mass General Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA., Zhang XH; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Wong STC; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA. stwong@houstonmethodist.org.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA. stwong@houstonmethodist.org.; Texas A&M University College of Medicine, Bryan, TX, USA. stwong@houstonmethodist.org.; Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA. stwong@houstonmethodist.org.; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA. stwong@houstonmethodist.org.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA. stwong@houstonmethodist.org.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. stwong@houstonmethodist.org.; Department of Bioengineering, Rice University, Houston, TX, USA. stwong@houstonmethodist.org.; Departments of Radiology, Medicine, and Urology, Houston Methodist Hospital, Houston, TX, USA. stwong@houstonmethodist.org.; Departments of Radiology, Neuroscience, Pathology and Laboratory Medicine, Weill Cornell Medicine, Houston, TX, USA. stwong@houstonmethodist.org. |
| Source: | Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 May 11; Vol. 11 (1). Date of Electronic Publication: 2026 May 11. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2059-3635 |
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| DOI: | 10.1038/s41392-026-02691-8 |
