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iS2C2: a cointelligent platform for mechanistic discovery of disease cellular crosstalk.

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Title: iS2C2: a cointelligent platform for mechanistic discovery of disease cellular crosstalk.
Authors: Sheng J; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA. jsheng@houstonmethodist.org.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA. jsheng@houstonmethodist.org., Ahn JY; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Texas A&M University College of Medicine, Bryan, TX, USA.; Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA., Yang L; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA. lyang@houstonmethodist.org.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA. lyang@houstonmethodist.org., Wan Z; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA., Qi S; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA., Yu X; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA., Xu Z; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Cao Y; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA., Vasquez M; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA., Irfan A; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA., Zhu Y; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Department of Bioengineering, Rice University, Houston, TX, USA., Zhao H; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA., Yin Z; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA., Zhu Y; Department of Genomic Medicine, University of Texas M.D. Anderson Cancer Center, Austin, TX, USA., Ding Y; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Faridar A; Departments of Radiology, Medicine, and Urology, Houston Methodist Hospital, Houston, TX, USA., Wang L; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA., Liu F; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Wang H; Department of Laboratory Medicine, University of Texas M.D. Anderson Cancer Center, Austin, TX, USA., Ji Z; Med-Surg units, Ben Taub Hospital, Austin, TX, USA., Mao D; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Chan M; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA., Kermany D; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Texas A&M University College of Medicine, Bryan, TX, USA.; Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA., Dong W; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA., Kim DY; Genetics and Aging Research Unit, Department of Neurology, Mass General Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA., Zhang XH; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Wong STC; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA. stwong@houstonmethodist.org.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA. stwong@houstonmethodist.org.; Texas A&M University College of Medicine, Bryan, TX, USA. stwong@houstonmethodist.org.; Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA. stwong@houstonmethodist.org.; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA. stwong@houstonmethodist.org.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA. stwong@houstonmethodist.org.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. stwong@houstonmethodist.org.; Department of Bioengineering, Rice University, Houston, TX, USA. stwong@houstonmethodist.org.; Departments of Radiology, Medicine, and Urology, Houston Methodist Hospital, Houston, TX, USA. stwong@houstonmethodist.org.; Departments of Radiology, Neuroscience, Pathology and Laboratory Medicine, Weill Cornell Medicine, Houston, TX, USA. stwong@houstonmethodist.org.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 May 11; Vol. 11 (1). Date of Electronic Publication: 2026 May 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: iS2C2: a cointelligent platform for mechanistic discovery of disease cellular crosstalk.
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  Data: <searchLink fieldCode="AU" term="%22Sheng+J%22">Sheng J</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA. jsheng@houstonmethodist.org.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA. jsheng@houstonmethodist.org.<br /><searchLink fieldCode="AU" term="%22Ahn+JY%22">Ahn JY</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Texas A&M University College of Medicine, Bryan, TX, USA.; Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA. lyang@houstonmethodist.org.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA. lyang@houstonmethodist.org.<br /><searchLink fieldCode="AU" term="%22Wan+Z%22">Wan Z</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Qi+S%22">Qi S</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Yu+X%22">Yu X</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Xu+Z%22">Xu Z</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Cao+Y%22">Cao Y</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Vasquez+M%22">Vasquez M</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Irfan+A%22">Irfan A</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Department of Bioengineering, Rice University, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Yin+Z%22">Yin Z</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Department of Genomic Medicine, University of Texas M.D. Anderson Cancer Center, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ding+Y%22">Ding Y</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Faridar+A%22">Faridar A</searchLink>; Departments of Radiology, Medicine, and Urology, Houston Methodist Hospital, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Liu+F%22">Liu F</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Laboratory Medicine, University of Texas M.D. Anderson Cancer Center, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ji+Z%22">Ji Z</searchLink>; Med-Surg units, Ben Taub Hospital, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Mao+D%22">Mao D</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Chan+M%22">Chan M</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Kermany+D%22">Kermany D</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Texas A&M University College of Medicine, Bryan, TX, USA.; Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA.<br /><searchLink fieldCode="AU" term="%22Dong+W%22">Dong W</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Kim+DY%22">Kim DY</searchLink>; Genetics and Aging Research Unit, Department of Neurology, Mass General Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+XH%22">Zhang XH</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wong+STC%22">Wong STC</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, USA. stwong@houstonmethodist.org.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Hospital, Houston, TX, USA. stwong@houstonmethodist.org.; Texas A&M University College of Medicine, Bryan, TX, USA. stwong@houstonmethodist.org.; Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA. stwong@houstonmethodist.org.; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA. stwong@houstonmethodist.org.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA. stwong@houstonmethodist.org.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. stwong@houstonmethodist.org.; Department of Bioengineering, Rice University, Houston, TX, USA. stwong@houstonmethodist.org.; Departments of Radiology, Medicine, and Urology, Houston Methodist Hospital, Houston, TX, USA. stwong@houstonmethodist.org.; Departments of Radiology, Neuroscience, Pathology and Laboratory Medicine, Weill Cornell Medicine, Houston, TX, USA. stwong@houstonmethodist.org.
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